BETA-CAROTENE ACCUMULATION IN SERUM AND SKIN
BETA-CAROTENE ACCUMULATION IN SERUM AND SKIN
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DOI：
10.1093/ajcn/57.2.175
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发表时间：
1993-02-01
影响因子：
7.1
通讯作者：
FRISOLI, JK
中科院分区：
文献类型：
--
作者：
PRINCE, MR;FRISOLI, JK
在人类志愿者中评估了β-胡萝卜素在血清和皮肤中的积累。在不含膳食脂肪的情况下，单次给予51毫克剂量的β-胡萝卜素，血清β-胡萝卜素没有检测到变化。给予相同剂量的200 g脂肪，40 h后血清β-胡萝卜素增加2.5倍。同样，与每天一次给予相同总剂量的β-胡萝卜素相比，每天分三次随餐给予β-胡萝卜素使血清β-胡萝卜素浓度升高三倍;两种方案的血清蓄积时间常数相同：9-10 d。皮肤颜色的汇款测量表明，β-胡萝卜素在皮肤中的积累被推迟了2周相比，血清中的积累。这些数据表明，β-胡萝卜素的吸收需要膳食脂肪，并通过随餐给药得到增强，但血清（10天）和组织（数周）积累的时间常数很长。
The accumulation of beta-carotene in serum an skin was evaluated in human volunteers. A single 51-mg dose of beta-carotene given in the absence of dietary fat resulted in no detectable change in serum beta-carotene. The same dose administered with 200 g fat increased serum beta-carotene 2.5-fold at 40 h. Similarly, administering beta-carotene daily in three divided doses with meals raised the serum beta-carotene concentration three times as high compared with the same total dose administered once a day; both regimens had the same time constant for serum accumulation: 9-10 d. Remittance measurements of skin color demonstrated that the accumulation of beta-carotene in skin was delayed by up to 2 wk compared with serum accumulation. These data indicate that beta-carotene absorption requires dietary fat and is enhanced by administering with meals but there is a long time constant for serum (10 d) and tissue (several weeks) accumulation.