Non-invasive methods of assessing angiogenesis and their value in predicting response to treatment in colorectal cancer
Non-invasive methods of assessing angiogenesis and their value in predicting response to treatment in colorectal cancer
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DOI：
10.1046/j.0007-1323.2001.01947.x
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发表时间：
2001-12-01
影响因子：
9.6
通讯作者：
Swift, RI
中科院分区：
文献类型：
--
作者：
George, ML;Dzik-Jurasz, ASK;Swift, RI
背景资料：肿瘤新血管生成可以通过测量外周循环中的血管生成细胞因子浓度和动态对比增强磁共振成像（DCE-MRI）进行非侵入性评估。本研究的目的是评估这些方法是否可以预测和监测直肠癌患者术前放化疗的治疗反应。方法：在定量肿瘤渗透性之前，检测了31例T-3/T-4直肠癌患者的血清和血浆血管内皮生长因子水平16例术前接受放化疗的患者进行了系列血管内皮生长因子（VEGF）和DCE-MRI测量。结果：治疗前血清VEGF水平与1 n K-transs水平相关（r = 0.48，P = 0.01）。反应性肿瘤（n = 8）的治疗前渗透性值高于非反应性肿瘤（n = 8）（平均1 n K-trans - 0.46和-0.72; P = 0.03）。与治疗前值相比，治疗结束时，反应性肿瘤的渗透性显著降低（平均1 n K-反式分别为-0.46和-0.86; P = 0.04）。治疗前血清VEGF水平没有统计学差异两组之间。结论：直肠谣言具有较高的渗透性，在介绍化疗放射治疗的反应比那些低渗透性。这可能允许预先选择适当的谣言，这些方案，与低渗透性肿瘤的患者正在考虑替代疗法。
Background: Tumour neoangiogenesis can be assessed non-invasively by measuring angiogenic cytokine concentrations in peripheral circulation and by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). The aim of this study was to assess whether these methods can predict and monitor response to treatment in patients with rectal cancer treated with preoperative chemoradiotherapy.Methods: Serum and plasma vascular endothelial growth factor levels were measured in 31 patients with T-3/T-4 rectal cancers before quantitating tumour permeability (1n K-trans) by DCE-MRI Sixteen patients receiving preoperative chemoradiotherapy had serial vascular endothelial growth factor (VEGF) and DCE-MRI measurements. Response to treatment was assessed using World Health Organization criteria.Results: Serum VEGF and 1n K-trans correlated before treatment (r = 0.48, P = 0.01). Responsive tumours (n = 8) had higher pretreatment permeability values than non-responsive tumours (n = 8) (mean 1n K-trans - 0.46 and - 0.72 respectively; P = 0.03). Compared with pretreatment values, responsive tumours showed a marked reduction in permeability at the end of treatment (mean 1n K-trans -0.46 and -0.86 respectively; P = 0.04). Pretreatment serum VEGF levels were not statistically different between the two groups.Conclusion: Rectal rumours with higher permeability, at presentation appear to respond better to chemo radio therapy than those of lower permeability. This may allow preselection of appropriate rumours for these regimens, with patients with low-permeability tumours being considered for alternative therapies.