Progesterone Receptor Signaling in the Uterus Is Essential for Pregnancy Success.
Progesterone Receptor Signaling in the Uterus Is Essential for Pregnancy Success.
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DOI：
10.3390/cells11091474
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发表时间：
2022-04-27
期刊：
影响因子：
6
通讯作者：
Monsivais, Diana
中科院分区：
文献类型：
--
作者：
Cope, Dominique I.;Monsivais, Diana
子宫在妇女的生殖健康中起着至关重要的作用，并控制着胚胎植入、胎盘发育、分娩和月经等关键过程。孕激素受体（PR）通过指导响应孕激素（P4）的转录程序来调节几种哺乳动物物种的生殖功能的关键方面。P4/PR信号传导控制早孕期子宫内膜容受性和蜕膜化，对成功妊娠的建立和结局至关重要。PR在整个妊娠期和分娩过程中也是必不可少的，并且它在子宫肌层中发挥关键作用，主要是通过其两种亚型孕酮受体A（PR-A）和孕酮受体B（PR-B）的专门功能，这两种亚型显示出作为转录调节剂的不同和独立的作用。本文就PR在蜕膜和子宫肌层中的作用作一综述。我们讨论了PR如何在胎盘哺乳动物中获得关键特征，从而在蜕膜中发挥高度专业化和动态作用。我们还总结了最近的文献，评估分娩时子宫肌层PR-A/PR-B比值，并讨论了目前治疗早产的有效性。
The uterus plays an essential role in the reproductive health of women and controls critical processes such as embryo implantation, placental development, parturition, and menstruation. Progesterone receptor (PR) regulates key aspects of the reproductive function of several mammalian species by directing the transcriptional program in response to progesterone (P4). P4/PR signaling controls endometrial receptivity and decidualization during early pregnancy and is critical for the establishment and outcome of a successful pregnancy. PR is also essential throughout gestation and during labor, and it exerts critical roles in the myometrium, mainly by the specialized function of its two isoforms, progesterone receptor A (PR-A) and progesterone receptor B (PR-B), which display distinct and separate roles as regulators of transcription. This review summarizes recent studies related to the roles of PR function in the decidua and myometrial tissues. We discuss how PR acquired key features in placental mammals that resulted in a highly specialized and dynamic role in the decidua. We also summarize recent literature that evaluates the myometrial PR-A/PR-B ratio at parturition and discuss the efficacy of current treatment options for preterm birth.
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影响因子：
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发表时间：
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影响因子：
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作者：
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DOI：
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发表时间：
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影响因子：
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