Complementary vasoactivity and matrix remodelling in arterial adaptations to altered flow and pressure
Complementary vasoactivity and matrix remodelling in arterial adaptations to altered flow and pressure
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DOI：
10.1098/rsif.2008.0254
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发表时间：
2009-03-06
影响因子：
3.9
通讯作者：
Humphrey, J. D.
中科院分区：
文献类型：
--
作者：
Valentin, A.;Cardamone, L.;Humphrey, J. D.
动脉表现出显著的适应生物力学负荷持续变化的能力，可能是通过类似地参与许多动脉病理和对治疗的反应的机制。特别值得注意的是，不同的数据表明，血管改变状态下的细胞和基质周转使动脉能够适应血流和压力的持续变化。本文的目标是明确显示改变的平滑肌收缩性和基质生长和重塑如何共同作用以适应代表性基底动脉的几何形状、结构、刚度和功能。为此，我们采用了连续体理论的约束混合物模型不断变化的墙壁，这取决于两个壁切应力诱导的变化，血管活性分子（改变平滑肌增殖和合成的基质）和壁内应力诱导的变化，生长因子（改变细胞和基质营业额）。例如，模拟表明，这些考虑有助于解释实验观察到的对增加流量与减少流量的适应率不同，以及对增加流量或压力的响应变化率的差异。
Arteries exhibit a remarkable ability to adapt to sustained alterations in biomechanical loading, probably via mechanisms that are similarly involved in many arterial pathologies and responses to treatment. Of particular note, diverse data suggest that cell and matrix turnover within vasoaltered states enables arteries to adapt to sustained changes in blood flow and pressure. The goal herein is to show explicitly how altered smooth muscle contractility and matrix growth and remodelling work together to adapt the geometry, structure, stiffness and function of a representative basilar artery. Towards this end, we employ a continuum theory of constrained mixtures to model evolving changes in the wall, which depend on both wall shear stress-induced changes in vasoactive molecules ( which alter smooth muscle proliferation and synthesis of matrix) and intramural stress-induced changes in growth factors (which alter cell and matrix turnover). Simulations show, for example, that such considerations help explain the different rates of experimentally observed adaptations to increased versus decreased flows as well as differences in rates of change in response to increased flows or pressures.