Circadian regulation of metabolism.
Circadian regulation of metabolism.
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DOI：
10.1530/joe-14-0200
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发表时间：
2014-08
期刊：
影响因子：
--
通讯作者：
Young ME
中科院分区：
文献类型：
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作者：
Bailey SM;Udoh US;Young ME
与睡眠/觉醒和禁食/进食周期相关，生物体在能量需求和营养供应方面经历了剧烈的振荡。因此，各种代谢参数，从分子能量传感器的活动状态到循环营养水平，以时间依赖的方式振荡，这并不奇怪。越来越清楚的是，代谢过程中的节律不仅仅是对日常环境/行为影响的反应，而是部分由细胞自主生物钟驱动的。通过使细胞与其环境同步，时钟以一种暂时适当的方式调节了许多代谢过程。本文的目的是回顾目前对生物钟与代谢之间相互作用的理解，以及在心脏代谢疾病发展方面破坏这种分子机制的病理生理后果。
In association with sleep/wake and fasting/feeding cycles, organisms experience dramatic oscillations in energetic demands and nutrient supply. It is therefore not surprising that various metabolic parameters, ranging from the activity status of molecular energy sensors to circulating nutrient levels, oscillate in time-of-day-dependent manners. It has become increasingly clear that rhythms in metabolic processes are not simply in response to daily environmental/behavioral influences, but are driven in part by cell autonomous circadian clocks. By synchronizing the cell with its environment, clocks modulate a host of metabolic processes in a temporally appropriate manner. The purpose of this article is to review current understanding of the interplay between circadian clocks and metabolism, in addition to the pathophysiologic consequences of disruption of this molecular mechanism, in terms of cardiometabolic disease development.