Skin allograft rejection in CD28-deficient mice
Skin allograft rejection in CD28-deficient mice
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DOI：
10.1097/00007890-199602150-00003
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发表时间：
1996-02-15
期刊：
影响因子：
6.2
通讯作者：
Ohashi, PS
中科院分区：
文献类型：
--
作者：
Kawai, K;Shahinian, A;Ohashi, PS
Costimulatory interactions between CD28 and the B7 family have been shown to augment T cell responses in general, To further assess the importance of the costimulatory signals generated through CD28, the allogeneic response was examined in CD28-deficient mice. T cells hom CD28-deficient mice showed reduced proliferation and cytokine production in response to allogeneic stimulator cells in vitro. However, CD28-deficient T cells developed cytotoxic activity against allogeneic target cells in vitro and efficiently rejected skin allografts in vivo. These results suggest that the costimulatory signals through CD28 are not essential for the induction of alloreactive effector functions in vitro or in vivo.
