Optical coherence tomography-based freeze-drying microscopy.
Optical coherence tomography-based freeze-drying microscopy.
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DOI：
10.1364/boe.3.000055
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发表时间：
2012-01-01
影响因子：
3.4
通讯作者：
Kessler WJ
中科院分区：
文献类型：
--
作者：
Mujat M;Greco K;Galbally-Kinney KL;Hammer DX;Ferguson RD;Iftimia N;Mulhall P;Sharma P;Pikal MJ;Kessler WJ
A new type of freeze-drying microscope based upon time-domain optical coherence tomography is presented here (OCT-FDM). The microscope allows for real-time, in situ 3D imaging of pharmaceutical formulations in vials relevant for manufacturing processes with a lateral resolution of <7 μm and an axial resolution of <5 μm. Correlation of volumetric structural imaging with product temperature measured during the freeze-drying cycle allowed investigation of structural changes in the product and determination of the temperature at which the freeze-dried cake collapses. This critical temperature is the most important parameter in designing freeze-drying processes of pharmaceutical products.
