EFFECTS OF HYDROCORTISONE AND IMMOBILIZATION ON TRYPTOPHAN-METABOLISM IN BRAIN AND LIVER OF RATS OF DIFFERENT AGES
EFFECTS OF HYDROCORTISONE AND IMMOBILIZATION ON TRYPTOPHAN-METABOLISM IN BRAIN AND LIVER OF RATS OF DIFFERENT AGES
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DOI：
10.1016/0006-2952(75)90248-8
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发表时间：
1975-01-01
影响因子：
5.8
通讯作者：
CURZON, G
中科院分区：
文献类型：
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作者：
GREEN, AR;CURZON, G
氢化可的松琥珀酸钠（5 mg/kg i. p.）导致年轻大鼠（26、46和66天）肝脏色氨酸吡咯酶活性的绝对增加大于老年大鼠（107和225天）。对照组动物的活动在老年大鼠中较低，百分比变化与年龄之间没有明显的相关性。雄性和雌性的反应相当。与以前的研究结果一致，脑5-羟色胺（5-HT）和5-羟吲哚乙酸（5-HIAA）减少6小时后，氢化可的松只有在年龄时，一个大的绝对增加吡咯酶活性发生（26，46和66天）。雄性和雌性动物氢化可的松给药前后的脑5-HT和5-HIAA水平相当。制动导致吡咯酶诱导和脑5-HT的变化在66天，但不是在225天的年龄大鼠。不同氢化可的松制剂的研究表明，可溶性琥珀酸盐比不溶性乙酸盐或游离碱引起吡咯酶活性更快的增加和更显著的脑5-HT降低。结果进行了讨论，建议肝脏色氨酸吡咯酶活性和随后的变化，在脑5-HT和5-HIAA之间的关联。
Hydrocortisone sodium succinate (5 mg/kg i.p.) led to a larger absolute increase in hepatic tryptophan pyrrolase activity in younger (26, 46 and 66 days) than older (107 and 225 days) rats. Activity in control animals was lower in the older rats and there was no obvious correlation between percentage change and age. Responses of male and females were comparable. Consistent with previous findings brain 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) decreased 6 hr after hydrocortisone only at ages when a large absolute increase of pyrrolase activity occurred (26, 46 and 66 days). Brain 5-HT and 5-HIAA levels both before and after hydrocortisone were comparable in males and females. Immobilization led to pyrrolase induction and brain 5-HT changes in 66-day but not in 225-day old rats. Studies with different hydrocortisone preparations showed that the soluble succinate salt caused a more rapid increase of pyrrolase activity than the insoluble acetate salt or free base and a more marked brain 5-HT decrease. Results are discussed in relation to the suggested association between liver tryptophan pyrrolase activity and the subsequent changes in brain 5-HT and 5-HIAA.