Effects of transdermal 17beta-estradiol on left ventricular anatomy and performance in hypertensive women.
Effects of transdermal 17beta-estradiol on left ventricular anatomy and performance in hypertensive women.
复制标题
透皮 17β-雌二醇对高血压女性左心室解剖和性能的影响。
作者：
M. G. Modena;N. Muià;P. Aveta;R. Molinari;R. Rossi
为了减少心血管并发症，降压治疗不仅要使血压正常，而且要诱导结构异常的消退，这些结构异常是终末器官损害的表现。我们研究了17β-雌二醇透皮吸收联合标准降压治疗对绝经后高血压妇女左心室解剖结构和收缩功能的影响。在一项随机、双盲、安慰剂对照研究中，我们招募了169名患有轻度或中度高血压的绝经后妇女。86例患者(第1组)口服17β-雌二醇(50微克/d)和25 mg/d醋酸炔诺酮(口服)，83例患者(第2组)接受安慰剂治疗。在基线时，所有女性都接受了M型和二维超声心动图，并在6个月、12个月和18个月的随访后重复进行。经过18个月的治疗，我们观察到两组患者的左室舒张期室间隔和后壁厚度及质量均显著降低。此外，18个月后，左心室重量明显小于雌激素治疗组。在左心室收缩和舒张期内径或收缩性能方面没有观察到明显的改变，如左室短轴缩短率所表示的。综上所述，与抗高血压治疗相关的经皮17β-雌二醇可能有助于减少绝经后高血压妇女的左心室重量。
To reduce cardiovascular complications, antihypertensive therapy should not only normalize blood pressure but also induce a regression of structural abnormalities, which are the expression of end-organ damage. We investigated the effects of transdermal 17beta-estradiol, combined with standard antihypertensive therapy, on the modification of left ventricular anatomy and systolic performance in hypertensive postmenopausal women. In a randomized, double-blind, placebo-controlled study, we enrolled 169 postmenopausal women with mild or moderate hypertension. Eighty-six patients (group 1) received transdermal 17beta-estradiol (50 microg/d) and norethisterone acetate (2.5 mg/d, orally), and 83 patients (group 2) received placebo. At baseline, all women underwent M-mode and 2-D echocardiogram, which was repeated after 6, 12, and 18 months of follow-up. After 18 months of treatment, we observed a significant decrease in left ventricular diastolic septal and posterior wall thickness and mass in both groups. Furthermore, after 18 months, left ventricular mass was significantly less than in the estrogen-treated group. No significant modifications were observed in left ventricular systolic and diastolic dimensions or in systolic performance, as expressed by left ventricular fractional shortening. In conclusion, transdermal 17beta-estradiol, which is associated with antihypertensive therapy, may contribute in the reduction of left ventricular mass in hypertensive postmenopausal women.
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DOI：
10.1016/0735-1097(94)90390-5
发表时间：
1994-05-01
影响因子：
24
作者：
DESIMONE, G;DEVEREUX, RB;LARAGH, JH
通讯作者：
LARAGH, JH
影响因子：
158.5
作者：
Grodstein, F;Stampfer, MJ;Speizer, FE
通讯作者：
Speizer, FE
DOI：
10.1016/0735-1097(92)90385-z
发表时间：
1992-11-01
影响因子：
24
作者：
DESIMONE, G;DANIELS, SR;ALDERMAN, MH
通讯作者：
ALDERMAN, MH
DOI：
10.1152/ajpcell.1994.266.4.c975
发表时间：
1994-04
期刊：
The American journal of physiology
影响因子：
--
作者：
F. Zhang;J. Ram;P. Standley;J. Sowers
通讯作者：
F. Zhang;J. Ram;P. Standley;J. Sowers
DOI：
10.1016/0735-1097(92)90617-v
发表时间：
1992-06-01
影响因子：
24
作者：
GANAU, A;DEVEREUX, RB;LARAGH, JH
通讯作者：
LARAGH, JH