Expression of cystathionine β-synthase is downregulated in hepatocellular carcinoma and associated with poor prognosis
Expression of cystathionine β-synthase is downregulated in hepatocellular carcinoma and associated with poor prognosis
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DOI：
10.3892/or_00000373
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发表时间：
2009-06-01
期刊：
影响因子：
4.2
通讯作者：
Kim, Dae Shick
中科院分区：
文献类型：
--
作者：
Kim, Jongmin;Hong, Seok Joo;Kim, Dae Shick
胱硫氨酸b合成酶（CBS）基因编码一种在反式硫化途径中催化胱硫氨酸合成的酶，由于其在抗氧化和甲基化代谢中的关键作用而受到严格调控。通过实时逆转录酶PCR （RT-PCR）评估的120例肝细胞癌（HCC）标本中CBS的表达水平明显低于周围非癌性肝脏(P
The cystathionine B-synthase (CBS) gene encodes an enzyme that catalyzes the synthesis of: cystathionine in the trans-sulfuration pathway and is Subject to tight regulation because of its critical role in antioxidant and methylation metabolism. The expression level of CBS in 120 hepatocellular carcinoma (HCC) specimens evaluated by real-time reverse transcriptase PCR (RT-PCR) is markedly lower than in surrounding non-cancerous liver (P