A microdroplet-based shift register
A microdroplet-based shift register
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DOI：
10.1039/c0lc00219d
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发表时间：
2010-01-01
期刊：
影响因子：
6.1
通讯作者：
Cooper, Jonathan M.
中科院分区：
文献类型：
--
作者：
Zagnoni, Michele;Cooper, Jonathan M.
介绍了一种油中微水滴的连续形成、储存和回收的微流控装置。其工作原理与电子移位寄存器相似。液滴被认为是信息的单位，可以在设备内排列和连续移动，从而可以控制乳剂的定位和液滴之间的界面。使用这种被动系统，由于设备设计，通过利用液滴上的流体动压和表面张力之间的平衡，液滴网络可以很容易地排列成一系列元素，并以自动化和高通量的方式级联在微通道内。结果表明，该体系适合于人工脂质双分子层的形成和基于分子通过界面扩散的生物动力学过程的研究。
A microfluidic device is presented for the serial formation, storage and retrieval of water microdroplets in oil. The principle of operation is similar to that of an electronic shift register. Droplets, considered as units of information, can be arrayed and serially shifted within the device, allowing the controllable positioning of the emulsions and the creation of interfaces between drops. Using this passive system, by exploiting the balance between hydrodynamic pressure and surface tension across a drop due to the device design, droplet networks can be readily arrayed in a series of elements and cascaded within the microchannels in an automatable and high throughput fashion. The results showed the suitability of the system to be used for the formation of artificial lipid bilayers and for the study of biological dynamic processes based on the diffusion of molecules through interfaces.