Fatty acid binding protein 4 in human skeletal muscle
Fatty acid binding protein 4 in human skeletal muscle
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DOI：
10.1016/j.bbrc.2006.05.083
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发表时间：
2006-07-21
影响因子：
3.1
通讯作者：
Jansson, E
中科院分区：
文献类型：
--
作者：
Fischer, H;Gustafsson, T;Jansson, E
调节肌细胞内三甘油（IMTG）储存和动员的机制在很大程度上尚不清楚。然而，在过去的几十年中，已经鉴定了几种细胞内脂肪酸结合蛋白（FABPs）。FABP 3是骨骼肌中的主要FABP。从FABP3缺失突变小鼠中的发现表明了另外的FABPs的表达。在本研究中，我们的目的是调查FABP4是否在骨骼肌纤维中表达，以及FABP3和FABP4是否在耐力训练的骨骼肌纤维中比对照组更丰富。我们发现FABP4蛋白在骨骼肌纤维中表达，并且FABP4 mRNA和蛋白在耐力训练的受试者中更丰富。尽管如此，FABP4的表达明显低于FABP3，FABP3是骨骼肌组织中普遍接受的主要FABP。(c)2006年爱思唯尔公司All rights reserved.
The mechanisms that regulate intramyocellular triglycerol (IMTG) storage and mobilization are largely unknown. However, during the last decades several intracellular fatty acid binding proteins (FABPs) have been identified. FABP3 is the dominating FABP in skeletal muscle. Expression of additional FABPs is suggested from findings in FABP3-null mutated mice. In the present study, our aims were to investigate if FABP4 is expressed within skeletal muscle fibers and if FABP3 and FABP4 are more abundant in skeletal muscle fibers in endurance-trained than in control subjects. We show that FABP4 protein is expressed within the skeletal muscle fibers and that FABP4 mRNA and protein are more abundant in the endurance trained subjects. Still, FABP4 is markedly less expressed than FABP3, which is the generally accepted dominating FABP in skeletal muscle tissue. (c) 2006 Elsevier Inc. All rights reserved.