Abdominal Obesity and Lung Cancer Risk: Systematic Review and Meta-Analysis of Prospective Studies.
Abdominal Obesity and Lung Cancer Risk: Systematic Review and Meta-Analysis of Prospective Studies.
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作者：
Hidayat K;Du X;Chen G;Shi M;Shi B
已经对观察性研究进行了多项荟萃分析，以检查通过体重指数（BMI）衡量的一般性肥胖与肺癌之间的关联。这些荟萃分析表明高 BMI 与这种癌症之间存在反比关系。与一般肥胖相反，腹部肥胖似乎在肺癌的发展中发挥作用。然而，腹部肥胖（通过腰围 (WC)（调整后的 BMI）和腰臀比 (WHR) 测量）与肺癌之间的关联尚不完全清楚，因为有关这种关联的现有证据很少。在 PubMed 和 Web of Science 数据库中检索了截至 2016 年 10 月评估腹部肥胖与肺癌之间关联的研究。使用随机效应模型计算了具有 95% 置信区间 (CI) 的相对风险 (RR) 汇总。我们的荟萃分析纳入了六项前瞻性队列研究，涉及 831,535 名参与者中的 5827 例肺癌病例。腰围每增加 10 厘米，腰臀比每增加 0.1 个单位，与 10%（RR 1.10；95% CI 1.04, 1.17；I2 = 27.7%，p 异质性 = 0.198）和 5%（RR 1.05；95% CI 1.00, 1.11；I2 = 25.2%）相关。 p-异质性 = 0.211) 分别增加肺癌风险。根据吸烟状况，较高的腰臀比仅与以前吸烟者的肺癌呈正相关（RR 1.11；95% CI 1.00，1.23）。相反，在从不吸烟者（RR 1.11；95% CI 1.00，1.23）、以前吸烟者（RR 1.12；95% CI 1.03，1.22）和当前吸烟者（RR 1.16；95% CI 1.08，1.25）中，WC越大，肺癌风险越高。 WC 和 WHR 最高类别与最低类别的汇总 RR 分别为 1.32（95% CI 1.13, 1.54；I2 = 18.2%，p 异质性 = 0.281）和 1.10（95% CI 1.00, 1.23；I2 = 24.2%，p 异质性 = 0.211）。综上所述，腹部肥胖可能在肺癌的发生发展中发挥重要作用。
Several meta-analyses of observational studies have been performed to examine the association between general obesity, as measured by body mass index (BMI), and lung cancer. These meta-analyses suggest an inverse relation between high BMI and this cancer. In contrast to general obesity, abdominal obesity appears to play a role in the development of lung cancer. However, the association between abdominal obesity (as measured by waist circumference (WC) (BMI adjusted) and waist to hip ratio (WHR)) and lung cancer is not fully understood due to sparse available evidence regarding this association. PubMed and Web of Science databases were searched for studies assessing the association between abdominal obesity and lung cancer up to October 2016. The summary relative risks (RRs) with 95% confidence intervals (CIs) were calculated with a random-effects model. Six prospective cohort studies with 5827 lung cancer cases among 831,535 participants were included in our meta-analysis. Each 10 cm increase in WC and 0.1 unit increase in WHR were associated with 10% (RR 1.10; 95% CI 1.04, 1.17; I2 = 27.7%, p-heterogeneity = 0.198) and 5% (RR 1.05; 95% CI 1.00, 1.11; I2 = 25.2%, p-heterogeneity = 0.211) greater risks of lung cancer, respectively. According to smoking status, greater WHR was only positively associated with lung cancer among former smokers (RR 1.11; 95% CI 1.00, 1.23). In contrast, greater WC was associated with increased lung cancer risk among never smokers (RR 1.11; 95% CI 1.00, 1.23), former smokers (RR 1.12; 95% CI 1.03, 1.22) and current smokers (RR 1.16; 95% CI 1.08, 1.25). The summary RRs for highest versus lowest categories of WC and WHR were 1.32 (95% CI 1.13, 1.54; I2 = 18.2%, p-heterogeneity = 0.281) and 1.10 (95% CI 1.00, 1.23; I2 = 24.2%, p-heterogeneity = 0.211), respectively. In summary, abdominal obesity may play an important role in the development of lung cancer.
影响因子：
8.8
作者：
Macauly, V M;Teale, J D;Everard, M J;Joshi, G P;Smith, I E;Millar, J L
通讯作者：
Millar, J L