Redox-Responsive MRI Probes Based on First-Row Transition-Metal Complexes
Redox-Responsive MRI Probes Based on First-Row Transition-Metal Complexes
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DOI：
10.1021/acs.inorgchem.2c02197
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发表时间：
2022-09-06
影响因子：
4.6
通讯作者：
Sahoo, Priya Ranjan
中科院分区：
文献类型：
--
作者：
Morrow, Janet R.;Raymond, Jaclyn J.;Sahoo, Priya Ranjan
第一行过渡金属配合物的多种氧化态和自旋态的存在促进了可切换 MRI 探针的开发。氧化还原响应探针利用顺磁性金属离子中心暴露于生物氧化剂和还原剂时不同氧化态的磁性变化。可用于 MRI 的过渡金属络合物可根据其是否加速水质子弛豫（T1 或 T2 试剂）、诱导 1H 或 19F 共振的顺磁位移（paraSHIFT 试剂）或化学交换饱和转移 (CEST) 试剂进行分类。总结了各种氧化态对及其作为 MRI 探针的特性，重点关注作为小分子或脂质体试剂的 Co(II)/Co(III) 或 Fe(II)/Fe(III) 复合物。对这些 MRI 探针的溶液研究进行了综述，重点是氧化剂或酶处理后的氧化还原变化，这些变化在炎症和疾病中具有重要的生理意义。最后，我们概述了进一步开发这些探针用于体内 MRI 应用的挑战。
The presence of multiple oxidation and spin states of first-row transition-metal complexes facilitates the development of switchable MRI probes. Redox-responsive probes capitalize on a change in the magnetic properties of the different oxidation states of the paramagnetic metal ion center upon exposure to biological oxidants and reductants. Transition-metal complexes that are useful for MRI can be categorized according to whether they accelerate water proton relaxation (T1 or T2 agents), induce paramagnetic shifts of 1H or 19F resonances (paraSHIFT agents), or are chemical exchange saturation transfer (CEST) agents. The various oxidation state couples and their properties as MRI probes are summarized with a focus on Co(II)/Co(III) or Fe(II)/Fe(III) complexes as small molecules or as liposomal agents. Solution studies of these MRI probes are reviewed with an emphasis on redox changes upon treatment with oxidants or with enzymes that are physiologically important in inflammation and disease. Finally, we outline the challenges of developing these probes further for in vivo MRI applications.