Apical versus Basal Neurogenesis Directs Cortical Interneuron Subclass Fate.
Apical versus Basal Neurogenesis Directs Cortical Interneuron Subclass Fate.
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DOI：
10.1016/j.celrep.2015.09.079
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发表时间：
2015-11-10
期刊：
影响因子：
8.8
通讯作者：
Anderson SA
中科院分区：
文献类型：
--
作者：
Petros TJ;Bultje RS;Ross ME;Fishell G;Anderson SA
哺乳动物端脑的命运决定，其多样性的神经元亚型和相关的神经精神疾病，仍然是一个关键领域的研究在神经科学。大多数研究集中在侧脑室沿着的空间和时间域内的神经祖细胞的多样性。经常被忽视的是，在一个命运限制域的神经发生的位置是否与不同的神经元命运相关，或具有指导意义。在这里，我们使用在体内的命运映射和操纵的神经源性的位置，以证明顶端与基底神经发生的影响来自皮质下端脑的皮质中间神经元的主要亚群的命运决定。生长抑素表达的中间神经元主要产生于心室表面沿着的顶端分裂，而小白蛋白表达的中间神经元主要起源于室下区的基底分裂。作为操纵，改变神经源性的位置改变interneuron亚类的命运，这些结果增加了一个额外的维度的时空决定因素的神经元的命运决定。
Fate determination in the mammalian telencephalon, with its diversity of neuronal subtypes and relevance to neuropsychiatric disease, remains a critical area of study in neuroscience. Most studies investigating this topic focus on the diversity of neural progenitors within spatial and temporal domains along the lateral ventricles. Often overlooked is whether the location of neurogenesis within a fate-restricted domain is associated with, or instructive for, distinct neuronal fates. Here, we use in vivo fate-mapping and the manipulation of neurogenic location to demonstrate that apical versus basal neurogenesis influences the fate determination of major subgroups of cortical interneurons derived from the subcortical telencephalon. Somatostatin-expressing interneurons arise mainly from apical divisions along the ventricular surface, whereas parvalbumin-expressing interneurons originate predominantly from basal divisions in the subventricular zone. As manipulations that shift neurogenic location alter interneuron subclass fate, these results add an additional dimension to the spatial-temporal determinants of neuronal fate determination.