Carotid intima-media thickness in patients with isolated coronary artery ectasia
Carotid intima-media thickness in patients with isolated coronary artery ectasia
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DOI：
10.1016/j.atherosclerosis.2006.02.015
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发表时间：
2007-02-01
期刊：
影响因子：
5.3
通讯作者：
Kiris, Abdulkadir
中科院分区：
文献类型：
--
作者：
Celik, Sukru;Erdogan, Turan;Kiris, Abdulkadir
目的：颈动脉内膜中层厚度（IMT）是目前广泛应用的动脉粥样硬化性疾病的替代指标。通过超声测量的颈动脉IMT已被证明与通过血管造影定义的冠状动脉疾病相关。然而.颈动脉IMT与孤立性冠状动脉扩张（CAE）之间的关系尚未研究。我们研究的目的是评估这种关系。方法：25例孤立性CAE无狭窄和25例对照组冠状动脉造影正常的患者被纳入本研究。结果：与冠状动脉造影正常的对照组相比，孤立性CAE患者的颈动脉IMT显着较高（分别为0.95 +/- 0.12和0.71 +/- 0.10 mm，p < 0.0001）。结论：本研究首次证实了颈动脉IMT增高与单纯性CAE之间的相关性，提示动脉粥样硬化可能参与了成人单纯性CAE的发病过程。(c)2006爱思唯尔爱尔兰有限公司保留所有权利。
Objective: Carotid artery intima-media thickness (IMT) is now widely used as a surrogate marker for atherosclerotic disease. Carotid IMT measured by ultrasound has been shown to be correlated with coronary artery disease as defined by angiography. However. the relation between carotid IMT and isolated coronary artery ectasia (CAE) has not been investigated. The aim of our study was to assess this relation.Methods: Twenty-five patients with isolated CAE Without stenosis and 25 control subjects with angiographically normal coronary arteries were included in this study. These were examined by B-mode ultrasound to measure the IMT at the far wall of the common carotid artery.Results: Patients with isolated CAE had significantly higher carotid IMT compared to control subjects with angiographically normal coronary arteries (0.95 +/- 0.12 versus 0.71 +/- 0.10 mm respectively, p < 0.0001). In addition, we detected a significant positive correlation between the presence of CAE and carotid IMT (r = 0.748, p < 0.001).Conclusion: We have shown for the first time an association between increased carotid IMT and isolated CAE, suggesting that atherosclerosis may be involved in the pathogenesis of isolated CAE in the adult population. (c) 2006 Elsevier Ireland Ltd. All rights reserved.