BROMOCRIPTINE SUPPRESSES THE THYROTROPHIN RESPONSE TO THYROTROPHIN RELEASING HORMONE DURING HUMAN PREGNANCY
BROMOCRIPTINE SUPPRESSES THE THYROTROPHIN RESPONSE TO THYROTROPHIN RELEASING HORMONE DURING HUMAN PREGNANCY
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溴隐亭抑制人类怀孕期间促甲状腺激素对促甲状腺激素释放激素的反应
DOI：
10.1111/j.1365-2265.1980.tb01051.x
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发表时间：
1980
影响因子：
3.2
通讯作者：
L. Viinikka
中科院分区：
文献类型：
--
作者：
O. Ylikorkala;S. Kivinen;L. Rönnberg;L. Viinikka
本文测定了15例正常早孕妇女静脉注射促甲状腺激素释放激素(TRH200μg)前后的促甲状腺激素反应。溴隐亭不改变妊娠期TSH、三碘甲状腺激素(T3)和甲状腺激素(T4)的基础水平。在开始使用溴隐亭前，TRH使促甲状腺激素水平从12.8±0.5μu/ml(平均值±SE)显著升高至21.2±1.9μu/ml。服溴隐亭期间，促甲状腺激素水平由11.9±0.4μu/ml升高至15.5±1.1μu/ml，较服药前显著降低(P<0.01)。溴隐亭前平均最大促甲状腺激素增量为8.4±1.5μu/ml，显著高于溴隐亭时3.8±60μu/ml(P<；0.001)。当妇女在合法流产前和流产后进行TRH复测时，溴隐亭没有改变TSH、T3和T4的基础水平，也没有改变TSH对TRH的反应。因此，溴隐亭对TSH的抑制作用与妊娠本身有关，但其抑制机制尚不清楚。
Thyrotrophin (TSH) responses to 200 μg ofintra venous thyrotrophin releasing hormone (TRH) were measured in fifteen healthy women in normal early pregnancy before and at the end of a bromocriptine treatment of 5·0–7·5 mg daily for 1–2 weeks. Bromocriptine did not change the basal levels of TSH, triiodothyrone (T3) and thyroxine (T4) during pregnancy. Before the start of bromocriptine, TRH caused a significant TSH elevation from 12·8 ±0·5 μu/ml (mean±SE) to 21·2 ±1·9 μu/ml after 20 min. During bromocriptine intake, TRH caused a TSH elevation from 11·9±0·4 μu/ml to only 15·5±1·1 μu/ml which is significantly less (P < 0·001) than before bromocriptine. Similarly, the mean maximal TSH increment of 8·4±1·5 μu/ml before bromocriptine was greater (P < 0·001) than that of 3·8±60 μu/ml during bromocriptine intake. When women were retested with TRH before and during bromocriptine after legal abortion, bromocriptine did not change the basal levels of TSH, T3 and T4 or the TSH response to TRH. Therefore, the TSH inhibition caused by bromocriptine is specifically related to the pregnancy itself, but the mechanism for this inhibition remains unknown.