Association of the OPRM1 and COMT genes' polymorphisms with the efficacy of morphine in Tunisian cancer patients: Impact of the high genetic heterogeneity in Tunisia?
Association of the OPRM1 and COMT genes' polymorphisms with the efficacy of morphine in Tunisian cancer patients: Impact of the high genetic heterogeneity in Tunisia?
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DOI：
10.1016/j.therap.2016.04.004
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发表时间：
2016-10-01
期刊：
影响因子：
2.6
通讯作者：
Libert, Frederic
中科院分区：
文献类型：
--
作者：
Chatti, Imen;Creveaux, Isabelle;Libert, Frederic
背景。-个体间阿片类药物反应差异的遗传原因是治疗效率的临床难点。本研究的目的是探讨阿片类药物治疗结果与突尼斯癌症疼痛患者的单核苷酸多态性（snp），阿片类受体（OPRM1）和儿茶酚-o-甲基转移酶（COMT）基因的可能关联。我们对129名接受不同剂量吗啡治疗的癌症患者进行了OPRM1基因（rs17174629、rs1799972和rs1799971）的3个snp和COMT基因（rs4680）的1个snp的基因分型。研究了剂量（连续）、剂量递增（是/否）与SNP或单倍型之间的关系。与其他针对白种人和中国人的研究不同，筛选的4种多态性与缓解疼痛所需的吗啡剂量之间没有显着关联。-与其他同质人群相比，这一结果可以通过突尼斯患者的遗传异质性和世界性来解释。(C) 2016法国药理学与治疗学会。Elsevier Masson SAS出版。版权所有。
Background. - Genetic causes for inter-individual variability response to opioids are clinical difficulties for treatment efficiency. The aim of the present study was to investigate the possible association of opioid treatment outcome with single nucleotide polymorphisms (SNPs) in the mi.', opioid receptor (OPRM1) and catechol-o-methyltransferase (COMT) genes, in Tunisian cancer pain patients.Methods. - We genotyped one hundred and twenty-nine cancer patients treated with different doses of morphine for 3 SNPs in OPRM1 gene (rs17174629, rs1799972 and rs1799971) and one in the COMT gene (rs4680). Associations between dose (continuous), dose escalation (yes/no) and SNP or haplotypes were investigated.Results. - Unlike other studies on Caucasian and Chinese populations, no significant association were found between the 4 polymorphisms screened and the dose of morphine needed for pain relief.Conclusion. - This result can be explained by the genetic heterogeneity and cosmopolitan areas of our Tunisian patients compared to the others homogenous population. (C) 2016 Societe francaise de pharmacologie et de therapeutique. Published by Elsevier Masson SAS. All rights reserved.