[Compound traditional Chinese medicine in treatment of diabetes].
[Compound traditional Chinese medicine in treatment of diabetes].
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DOI：
10.19540/j.cnki.cjcmm.20181212.001
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发表时间：
2019-03-01
期刊：
影响因子：
--
通讯作者：
Tu, Jun
中科院分区：
文献类型：
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作者：
Wu, Qing-Hua;Li, Bing-Tao;Tu, Jun
糖尿病是一种以血糖水平升高为特征的慢性葡萄糖代谢紊乱。随着人们生活水平的提高和生活方式的改变，近几十年来，T2 DM发病率急剧上升，带来了一系列的公共卫生问题。在糖尿病药物的研发领域，T1 DM药物以长效缓释胰岛素制剂为主，T2 DM药物以单靶点为主。2型糖尿病药物通常具有良好的降糖作用，但长期服用会产生副作用。因此，降血糖药物的研发重点是多成分、多靶点、多途径作用的配方药物。在相似的作用原理下，中药方剂在治疗糖尿病方面取得了较好的疗效，具有温和的降血糖作用和多组分协同作用，在干预糖尿病的发病机制方面具有相加作用、协同作用和毒性分散作用。本文主要对中药方剂治疗糖尿病的临床试验及作用机制进行综述，以期为临床合理有效地应用中药方剂治疗糖尿病提供参考。
Diabetes is a chronic disorder of glucose metabolism characterized by elevated blood glucose levels. With the improvement in living standards and the changes in lifestyle,T2 DM incidence has a dramatic increase in the past decades,bringing a series of public health problems. In the research and development field of diabetic drugs,T1 DM drugs are mainly long-acting sustained-release insulin preparations,whereas T2 DM drugs mainly are based on single target. T2 DM drugs usually have a good anti-hyperglycemic effect,but with side effects for long-term administration. Therefore,the research and development of hypoglycemic drugs focus on formula drugs with multi-component,multi-target and multi-pathway effects. In the similar principle of action,traditional Chinese medicine formula has achieved a good efficacy in the treatment of diabetes,with mild anti-hyperglycemic effects and multiple-component synergistic effects in intervening the pathogenesis of diabetes,including additive effect,synergy effect and toxicity scattering effect. This article mainly reviews clinical trials and mechanisms of action of traditional Chinese medicine formula for the treatment of diabetes,so as to provide a reference to the rational and effective clinical application of traditional Chinese medicine formula in treating diabetes.