Stem cells and heterotopic ossification: Lessons from animal models.
Stem cells and heterotopic ossification: Lessons from animal models.
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DOI：
10.1016/j.bone.2018.01.029
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发表时间：
2018-04
期刊：
影响因子：
4.1
通讯作者：
Goldhamer DJ
中科院分区：
文献类型：
--
作者：
Lees-Shepard JB;Goldhamer DJ
最简单地说，异位骨化（HO）是骨骼在骨外部位的异常形成。HO可分为两种主要亚型，遗传性和获得性。获得性HO是主要结缔组织损伤、创伤性中枢神经系统损伤和手术干预的常见并发症，可引起显著疼痛和术后残疾。HO的一种特别具有破坏性的形式表现在罕见的遗传性疾病中，进行性骨化性纤维发育不良（FOP），其中进行性异位骨形成在整个生命中发生，导致疼痛和致残的累积性不动。虽然干/祖细胞群在HO中的中心作用已经牢固确立，但引起损伤的细胞类型的身份仍有待最终确定，并且对指导这些祖细胞启动软骨和骨形成的机制知之甚少。在这篇综述中，我们总结了目前的知识，负责获得HO和FOP的细胞，突出的优点和缺点的动物模型用于询问HO的细胞起源。
Put most simply, heterotopic ossification (HO) is the abnormal formation of bone at extraskeletal sites. HO can be classified into two main subtypes, genetic and acquired. Acquired HO is a common complication of major connective tissue injury, traumatic central nervous system injury, and surgical interventions, where it can cause significant pain and postoperative disability. A particularly devastating form of HO is manifested in the rare genetic disorder, fibrodysplasia ossificans progressiva (FOP), in which progressive heterotopic bone formation occurs throughout life, resulting in painful and disabling cumulative immobility. While the central role of stem/progenitor cell populations in HO is firmly established, the identity of the offending cell type(s) remains to be conclusively determined, and little is known of the mechanisms that direct these progenitor cells to initiate cartilage and bone formation. In this review, we summarize current knowledge of the cells responsible for acquired HO and FOP, highlighting the strengths and weaknesses of animal models used to interrogate the cellular origins of HO.
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影响因子：
64.8
作者：
Chen, Michael J.;Yokomizo, Tomomasa;Zeigler, Brandon M.;Dzierzak, Elaine;Speck, Nancy A.
通讯作者：
Speck, Nancy A.
影响因子：
4.6
作者：
Agarwal S;Loder S;Cholok D;Peterson J;Li J;Fireman D;Breuler C;Hsieh HS;Ranganathan K;Hwang C;Drake J;Li S;Chan CK;Longaker MT;Levi B
通讯作者：
Levi B
DOI：
10.1002/jbmr.2820
发表时间：
2016-09
期刊：
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
影响因子：
--
作者：
Chakkalakal SA;Uchibe K;Convente MR;Zhang D;Economides AN;Kaplan FS;Pacifici M;Iwamoto M;Shore EM
通讯作者：
Shore EM
影响因子：
37.8
作者：
Farrington-Rock, C;Crofts, NJ;Canfield, AE
通讯作者：
Canfield, AE
影响因子：
--
作者：
Friedrichs M;Wirsdöerfer F;Flohé SB;Schneider S;Wuelling M;Vortkamp A
通讯作者：
Vortkamp A