Stereocomplex block copolymer micelles:: Core-shell nanostructures with enhanced stability
Stereocomplex block copolymer micelles:: Core-shell nanostructures with enhanced stability
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DOI：
10.1021/nl048037v
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发表时间：
2005-02-01
期刊：
影响因子：
10.8
通讯作者：
Leroux, JC
中科院分区：
文献类型：
--
作者：
Kang, N;Perron, MÉ;Leroux, JC
通过聚乙二醇嵌段-聚(L-丙交酯)和聚(乙二醇)-嵌段-聚(D-丙交酯)等摩尔混合物在水中自组装得到单分散立体复合嵌段共聚物胶束。这些胶束具有部分结晶的核心，平均流体动力学直径范围为 31 至 56 nm，具体取决于丙交酯含量。它们表现出优于单独用全同立构或外消旋聚合物制备的胶束的动力学稳定性和再分散特性。这项研究证明了立体复合物形成在稳定的水溶性纳米颗粒设计中的优势。
Monodisperse stereocomplex block copolymer micelles were obtained through the self-assembly of equimolar mixtures of poly(ethylene glycol)block-poly(L-lactide) and poly(ethylene glycol)-block-poly(D-lactide) in water. These micelles possessed partially crystallized cores and mean hydrodynamic diameters ranging from 31 to 56 nm, depending on the lactide content. They exhibited kinetic stability and redispersion properties superior to micelles prepared with isotactic or racemic polymers alone. This study demonstrates the advantages of stereocomplex formation in the design of stabilized water-soluble nanoparticles.