Increased glycolytic substrate protection improves ischemic cardiac dysfunction and reduces injury
Increased glycolytic substrate protection improves ischemic cardiac dysfunction and reduces injury
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DOI：
10.1067/mhj.2000.103920
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发表时间：
2000-02-01
影响因子：
4.8
通讯作者：
Apstein, CS
中科院分区：
文献类型：
--
作者：
Apstein, CS
葡萄糖-胰岛素-钾治疗急性心肌梗死的早期临床试验尚无定论。然而，最近的几项安慰剂对照、前瞻性、随机临床试验表明，葡萄糖-胰岛素-钾在心脏手术期间和之后用于急性心肌梗死或代谢支持的疗效。这些临床结果得到了实验研究的支持，实验研究表明，增加糖酵解底物对缺血心肌具有很强的保护作用，并改善了生物能量状态。
Early clinical trials of glucose-insulin-potassium for acute myocardial infarction were inconclusive. However, several recent placebo-controlled, prospective, randomized clinical trials of glucose-insulin-potassium for acute myocardial infarction or metabolic support during and after cardiac surgery have demonstrated its efficacy. These clinical results are supported by experimental studies that have shown a strong protective effect of increased glycolytic substrate on ischemic myocardium in concert with an improved bioenergetic status.