An Oligovascular Niche: Cerebral Endothelial Cells Promote the Survival and Proliferation of Oligodendrocyte Precursor Cells
An Oligovascular Niche: Cerebral Endothelial Cells Promote the Survival and Proliferation of Oligodendrocyte Precursor Cells
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DOI：
10.1523/jneurosci.0035-09.2009
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发表时间：
2009-04-08
影响因子：
5.3
通讯作者：
Lo, Eng H.
中科院分区：
文献类型：
--
作者：
Arai, Ken;Lo, Eng H.
我们发现，脑内皮细胞分泌营养因子，支持大鼠少突胶质细胞前体细胞（OPCs）的生存和增殖。这种OPC支持现象是由Akt和Src信号通路介导的。非细胞毒性水平的氧化应激下调营养因子的产生，破坏脑内皮细胞支持OPCs的能力。这些数据表明，一个新的寡血管生态位可能是重要的，维持少突胶质细胞的更新和稳态哺乳动物大脑。
We show that cerebral endothelial cells secrete trophic factors that support the survival and proliferation of rat oligodendrocyte precursor cells (OPCs). This OPC-supportive phenomenon was mediated by Akt and Src signaling pathways. Noncytotoxic levels of oxidative stress downregulate trophic factor production and disrupt the ability of cerebral endothelial cells to support OPCs. These data suggest that a novel oligovascular niche may be important for sustaining oligodendrocyte renewal and homeostasis in mammalian brain.