Role of β-lactamases and porins in resistance to ertapenem and other β-lactams in Klebsiella pneumoniae
Role of β-lactamases and porins in resistance to ertapenem and other β-lactams in Klebsiella pneumoniae
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DOI：
10.1128/aac.48.8.3203-3206.2004
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发表时间：
2004-08-01
影响因子：
4.9
通讯作者：
Chow, N
中科院分区：
文献类型：
--
作者：
Jacoby, GA;Mills, DM;Chow, N
在Omp 35和Omp 36缺陷的肺炎克雷伯菌菌株中，1、2f和3组β-内酰胺酶产生了对厄他培南的高水平耐药性。从产生ACT-1 β-内酰胺酶的野生型菌株中，可以选择厄他培南抗性突变体，其厄他培南MIC高达128 μ g/ml，并且外膜蛋白的表达减少。
High-level resistance to ertapenem was produced by beta-lactamases of groups 1, 2f, and 3 in a strain of Klebsiella pneumoniae deficient in Omp35 and Omp36. From a wild-type strain producing ACT-1 beta-lactamase, ertapenem-resistant mutants for which the ertapenem MICs were up to 128 mug/ml and expression of outer membrane proteins was diminished could be selected.