Treatment with supplementary arginine, vitamin C and zinc in patients with pressure ulcers: A randomised controlled trial
Treatment with supplementary arginine, vitamin C and zinc in patients with pressure ulcers: A randomised controlled trial
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DOI：
10.1016/j.clnu.2005.06.011
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发表时间：
2005-12-01
影响因子：
6.3
通讯作者：
Crowe, TC
中科院分区：
文献类型：
--
作者：
Desneves, KJ;Todorovic, BE;Crowe, TC
背景和目标：在临床setting.Methods：16例住院患者的阶段2，3或4压力溃疡随机接受每天一个标准的医院饮食，一个标准的饮食加两个高蛋白/能量补充剂，或一个标准的饮食加两个高蛋白/能量补充剂含有额外的精氨酸（9克），维生素C（500毫克）和锌（30毫克）。每周测量一次营养状况（饮食、人体测量和生物化学）和压疮大小和严重程度（通过PUSH too[;加热压疮量表; 0 =完全加热，17 =最严重程度），持续3周。结果：患者的年龄和BMI范围分别为37-92岁和16.4-28.1 kg/m2。两组之间的基线PUSH评分相似（8.7 ± 0.5）。只有接受额外精氨酸、维生素C和锌治疗的患者显示出压疮发热的临床显著改善（基线和第3周分别为9.4 +/- 1.2 vs. 2.6 +/- 0.6; P < 0.01）。所有患者组均表现为低血清白蛋白和低锌以及C反应蛋白升高。在任何group.Conclusions生化指标，口服饮食摄入量或体重没有显着变化：在这一小组的患者，补充精氨酸，维生素C和锌显着提高压疮加热率。这些结果需要在更大规模的研究中得到证实。(c)2005年爱思唯尔有限公司和欧洲临床营养与代谢学会。All rights reserved.
Background Et Aims: Nutrients putatively implicated in pressure ulcer heating were evaluated in a clinical setting.Methods: Sixteen inpatients with a stage 2, 3 or 4 pressure ulcer randomised to receive daily a standard hospital diet; a standard diet plus two high-protein/energy supplements; or a standard diet plus two high-protein/ energy supplements containing additional arginine (9 g), vitamin C (500 mg) and zinc (30 mg). Nutritional status measurements (dietary, anthropometric and biochemical) and pressure ulcer size and severity (by PUSH too[; Pressure Ulcer Scale for Heating; 0 = completely heated, 17 = greatest severity) were measured weekly for 3 weeks.Results: Patients' age and BMI ranges were 37-92 years and 16.4-28.1 kg/m(2), respectively. Baseline PUSH scores were similar between groups (8.7 +/- 0.5). Only patients receiving additional arginine, vitamin C and zinc demonstrated a clinically significant improvement in pressure ulcer heating (9.4 +/- 1.2 vs. 2.6 +/- 0.6; baseline and week 3, respectively; P < 0.01). All patient groups presented with low serum albumin and zinc and elevated C-reactive protein. There were no significant changes in biochemical markers, oral dietary intake or weight in any group.Conclusions: In this small set of patients, supplementary arginine, vitamin C and zinc significantly improved the rate of pressure ulcer heating. The results need to be confirmed in a larger study. (c) 2005 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.