The influence of nutritional factors on the prognosis of multiple sclerosis.
The influence of nutritional factors on the prognosis of multiple sclerosis.
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营养因素对多发性硬化症预后的影响。
DOI：
10.1038/nrneurol.2012.194
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发表时间：
2012
期刊：
影响因子：
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通讯作者：
Mowry,EllenM
中科院分区：
文献类型：
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作者：
vonGeldern,Gloria;Mowry,EllenM
营养和膳食补充剂对多发性硬化症（MS）病程的影响是患者和临床医生都非常感兴趣的话题。特别是，维生素D水平已被证明影响多发性硬化症的发病率和病程，高维生素D水平可能对多发性硬化症的发展有保护作用，尽管补充维生素D在减缓多发性硬化症进展方面的功效仍有待确定。多不饱和脂肪酸（PUFAs）对多发性硬化症的发展和过程的影响也一直被研究。小型临床试验表明，接受PUFA补充剂的多发性硬化症患者复发的严重程度和持续时间略有降低。其他营养因子已被评估对MS疾病进展的影响，包括牛奶蛋白、麸质、益生菌、抗氧化剂（尿酸、维生素A、C和E、硫辛酸）、多酚、银杏叶提取物和姜黄素。然而，需要进一步的研究来评估这些饮食成分对多发性硬化症复发率和进展的影响。本综述概述了最常被认为对多发性硬化症有影响的营养因素的文献，并讨论了被认为是其影响基础的生物学原理。
The effect of nutrition and dietary supplements on the course of multiple sclerosis (MS) is a topic of great interest to both patients and clinicians. In particular, vitamin D status has been shown to influence both the incidence and the course of MS. High vitamin D levels are probably protective against the development of MS, although the efficacy of vitamin D supplementation in slowing progression of MS remains to be established. The influence of polyunsaturated fatty acids (PUFAs) on the development and course of MS has also long been under investigation. Small clinical trials suggest a modest reduction in the severity and duration of relapses in patients with MS receiving PUFA supplements. Other nutritional factors have been evaluated for their effect on MS disease progression, including milk proteins, gluten, probiotics, antioxidants (uric acid, vitamins A, C and E, lipoic acid), polyphenols, Ginkgo biloba extracts and curcumin. However, further studies are needed to evaluate the effects of these dietary components on the relapse rate and progression of MS. This Review gives an overview of the literature on the nutritional factors most commonly implicated as having an effect on MS and discusses the biological rationale that is thought to underlie their influence.