The role of depression and anxiety in onset of diabetes in a large population-based study
The role of depression and anxiety in onset of diabetes in a large population-based study
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DOI：
10.1016/j.jpsychores.2006.07.009
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发表时间：
2007-01-01
影响因子：
4.7
通讯作者：
Engum, Anne
中科院分区：
文献类型：
--
作者：
Engum, Anne
目的：最近的研究表明，抑郁可能预示着糖尿病的发生。这项研究的目的是调查抑郁和焦虑的症状是否先于糖尿病的发作，反之亦然，并检查中介因素是否可以解释这种关联。研究方法：进行了一项基于人群的前瞻性研究（N= 37，291），调查抑郁/焦虑症状与糖尿病之间的关联。结果：在基线时报告抑郁和焦虑症状的个体在10年随访时发生2型糖尿病的风险增加。没有发现性别差异，分析也没有揭示潜在的因素介导的关联。在男性或女性中，糖尿病的基线诊断与随后的焦虑或抑郁症状无关。结论：糖尿病不能预测抑郁或焦虑症状。抑郁和焦虑症状是2型糖尿病发病的重要危险因素，独立于糖尿病的既定危险因素，如社会经济因素，生活方式因素和代谢综合征标志物。抑郁和焦虑的共病可能是最重要的因素。(c)2007年爱思唯尔公司All rights reserved.
Objective: Recent research has shown that depression may predict incident diabetes. The aims of the study are to investigate if symptoms of depression and anxiety precede the onset of diabetes or vice versa and to examine if mediating factors may explain such associations. Methods: A prospective population-based study (N=37,291) investigating the associations between symptoms of depression/anxiety and diabetes was conducted. Results: Individuals reporting symptoms of depression and anxiety at baseline had increased risk of onset of type 2 diabetes at 10-year follow-up. No gender differences were found. The analyses did not reveal underlying factors that mediated the association. Baseline diagnosis of diabetes was not associated with subsequent symptoms of anxiety or depression among males or females. Conclusion: Diabetes did not predict symptoms of depression or anxiety. Symptoms of depression and anxiety emerged as significant risk factors for onset of type 2 diabetes independent of established risk factors for diabetes, such as socioeconomic factors, lifestyle factors, and markers of the metabolic syndrome. The comorbidity between depression and anxiety may be the most important factor. (c) 2007 Elsevier Inc. All rights reserved.