Biomolecule-based switching devices that respond inversely to thermal stimuli.
Biomolecule-based switching devices that respond inversely to thermal stimuli.
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DOI：
10.1021/ja044138j
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发表时间：
2005-01
影响因子：
15
通讯作者：
Ryu Tashiro;H. Sugiyama
中科院分区：
文献类型：
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作者：
Ryu Tashiro;H. Sugiyama
我们展示了一个分子开关，DNA和RNA的特征性质的基础上，这表明一个完全反转的热刺激反应使用之间的过渡右手和左手螺旋。我们设计了一个使用氨基嘌呤（Ap）的系统，该系统可以将从右手到左手的DNA（B-Z跃迁）和RNA（A-Z跃迁）的π堆叠信息转换为给出荧光信号的输出。这两个生物分子装置一起充当“右-左”或“关-开”开关。当温度从低变到高时，RNA设备从关闭信号变为打开信号;然而，DNA设备从打开变为关闭。这些基于RNA和DNA的装置对热刺激的响应是完全可逆的。
We demonstrate a molecular switch, on the basis of the characteristic properties of DNA and RNA, which indicates a completely inverted response to thermal stimuli using the transition between right- and left-handed helices. We designed a system using aminopurine (Ap), which can convert the pi-stack information of the transition from right-handed to left-handed DNA (B-Z transition) and RNA (A-Z transition) into an output giving a fluorescent signal. These two biomolecular devices together serve as "right-left" or "off-on" switches. When the temperature is changed from low to high, the RNA device changes from the off to on signal; however, the DNA device changes from on to off. The response of these RNA and DNA based devices against thermal stimulus was completely reversible.