Regulating polymer adsorption on colloid by surface morphology
Regulating polymer adsorption on colloid by surface morphology
复制标题
通过表面形貌调节聚合物在胶体上的吸附
作者：
Wang Chao;Yan Feng;Meng Xiaohui;Qiao Yan;Qiu Dong
高分子在胶体颗粒上的吸附研究已引起人们的广泛关注。在这项工作中，我们研究了两种互补的形态，其中一个具有凸起（树莓状）的表面上，而另一个具有孔（草莓状）的基板胶体颗粒上的聚合物吸附。与凸起相比，发现胶体颗粒上的孔阻止聚合物吸附，并且这种效果取决于聚合物线圈和孔的相对尺寸。这种表面形态效应主要归因于当聚合物线圈的流体动力学尺寸大于孔时，由于尺寸限制效应，降低了聚合物对孔中吸附位点的可及性。当聚合物线圈的流体动力学尺寸小于孔的流体动力学尺寸时，在树莓状和草莓状胶体之间观察到聚合物吸附没有差异。这项研究提供了一种策略，通过调整表面上的精细结构，这可能是有利的，当允许有限的化学组成，用于调节聚合物吸附在胶体颗粒上。例如，当使用具有表面孔的胶体时，可以发现胶体药物上的蛋白质吸附显著减少。
The study of polymer adsorption on colloidal particles has attracted intensive attention. In this work, we investigated polymer adsorption on substrate colloidal particles with two complementary morphologies, one of which has bulges (raspberry-like) on the surface and the other of which has holes instead (strawberry-like). Compared to the bulges, the holes on the colloidal particles were found to prevent polymer adsorption and this effect was dependent on the relative dimensions of the polymer coil and hole. This surface morphology effect was attributed mainly to the reduced polymer accessibility to the adsorption sites in holes when the hydrodynamic size of the polymer coil is larger than the hole, due to the size limiting effect. When the hydrodynamic size of the polymer coil is smaller than that of the holes, no difference in polymer adsorption was observed between raspberry-like and strawberry-like colloids. This study provides a strategy for regulating polymer adsorption on colloidal particles by adjusting the fine structures on the surface, which may be advantageous when limited chemical compositions are allowed. For example, protein adsorption on colloidal drugs may be found to be significantly reduced when colloids with surface holes are used.