Apoptotic neurodegeneration in the context of traumatic injury to the developing brain
Apoptotic neurodegeneration in the context of traumatic injury to the developing brain
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DOI：
10.1016/j.etp.2004.04.006
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发表时间：
2004-10-01
影响因子：
--
通讯作者：
Ikonomidou, C
中科院分区：
文献类型：
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作者：
Bittigau, P;Sifringer, M;Ikonomidou, C
头部创伤是儿科人群死亡和残疾的主要原因。最近的一些关于发育中大脑创伤性损伤的神经病理学和生物化学特征的研究揭示了未来研究的有趣方面和潜在目标。创伤在发育中的大鼠大脑中触发兴奋毒性和凋亡性神经变性。凋亡性神经变性以延迟的方式在数天内发生，并且以年龄依赖性的方式导致头部创伤后的神经病理学结果，其中未成熟的大脑非常敏感。生物化学研究表明，外源性和内源性凋亡途径都参与了发育中大脑创伤后凋亡细胞死亡的发病机制，并且半胱天冬酶抑制剂改善了婴儿头部创伤模型中的凋亡性神经变性。干预细胞凋亡途径可能是儿科创伤性脑损伤的潜在治疗靶点。(C)2004年Elsevier GmbH。All rights reserved.
Head trauma is the leading cause of death and disability in the pediatric population. Some recent studies on neuropathological and biochemical features of traumatic injury to the developing brain revealed interesting aspects and potential targets for future research.Trauma triggers both excitotoxic and apoptotic neurodegeneration in the developing rat brain. Apoptotic neurodegeneration occurs in a delayed fashion over several days and contributes in an age-dependent fashion to neuropathologic outcome following head trauma, with the immature brain being exceedingly sensitive. Biochemical studies indicate that both the extrinsic and the intrinsic apoptotic pathways are involved in pathogenesis of apoptotic cell death following trauma in the developing brain and that caspase inhibition ameliorates apoptotic neurodegeneration in an infant head trauma model.Given the major contribution of apoptotic neurodegeneration to neuropathologic outcome following trauma to the developing brain, interference with apoptotic pathways may comprise a potential therapeutic target in pediatric traumatic brain injury. (C) 2004 Elsevier GmbH. All rights reserved.