Effect of neuropeptide B on feeding behavior is influenced by endogenous corticotropin-releasing factor activities
Effect of neuropeptide B on feeding behavior is influenced by endogenous corticotropin-releasing factor activities
复制标题
DOI：
10.1016/j.regpep.2008.08.001
复制
发表时间：
2008-11-29
影响因子：
--
通讯作者：
Sakurai, Takeshi
中科院分区：
文献类型：
--
作者：
Aikawa, Shizu;Ishii, Makoto;Sakurai, Takeshi
摄食量减少是哺乳动物对应激反应的常见现象。促肾上腺皮质激素释放因子（CRF）是一种调节这些应激条件下摄食行为的因子。我们以前报道过神经肽B（NPB）与CRF联合给药对小鼠产生强烈的协同减食欲作用。神经肽B/W受体1（NPBWR 1）和NPB的组织分布表明，该神经肽系统也在调节情绪和应激反应中发挥作用。在这项研究中，我们检查了NPB的作用是否会被内源性CRFergic张力改变。在光明时期。当小鼠脑室内给予NPB时，单独使用NPB对进食行为没有任何影响;然而，当与强效非选择性CRF受体拮抗剂astressin联合给药时，NPB增加了食物摄入量。另一方面，在黑暗期，NPB的管理导致了强烈的抑制摄食行为。当同时给予astressin时，这些作用几乎完全消失。最后，在手术应激后，一种半慢性应激源，NPB对小鼠产生了强有力的厌食作用。与此形成鲜明对比的是，在手术应激条件下，联合施用astressin和NPB增加了食物摄入。这些数据表明，NPB的作用很大程度上受内源性CRF能紧张。(C)2008 Elsevier B. V.保留所有权利。
Decrease in food intake is commonly seen in the mammalian response to stress. Corticotropin-releasing factor (CRF) is a factor that modulates feeding behavior under these stressful conditions. We previously reported that neuropeptide B (NPB) exerts strong synergistic anorectic effects in mice when co-administered with CRF. Tissue distributions of neuropeptide B/W receptor-1 (NPBWR1) and NPB suggest that this neuropeptide system also plays a role in regulating emotion and stress responses. In this study, we examined whether the effects of NPB are altered by endogenous CRFergic tone. During the light period. NPB alone did not show any effect on feeding behavior when administered intracerebroventricularly in mice; however, NPB increased food intake when co-administered with astressin, a potent non-selective CRF receptor antagonist. On the other hand, during the dark period, administration of NPB resulted in a strong inhibition of feeding behavior. The effects were almost completely abolished when astressin was co-administered. Finally, after surgical stress, a semi-chronic stressor, NPB exerted potent anorectic effects on mice. In striking contrast, co-administration of astressin and NPB increased food intake under surgical stress conditions. These data suggest that the effects of NPB are greatly influenced by the endogenous CRFergic tone. (C) 2008 Elsevier B.V. All rights reserved.