Recent developments in microfluidic devices for in vitro cell culture for cell-biology research
Recent developments in microfluidic devices for in vitro cell culture for cell-biology research
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用于细胞生物学研究的体外细胞培养的微流体装置的最新进展
DOI：
10.1016/j.trac.2012.02.008
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发表时间：
2012-05-01
影响因子：
13.1
通讯作者：
Lin, Jin-Ming
中科院分区：
文献类型：
--
作者：
Gao, Dan;Liu, Hongxia;Lin, Jin-Ming
微流控由于其固有的优势，已发展成为细胞生物学研究的强大工具。近年来，用于细胞培养和操作以及后续处理和分析的微流控技术取得了长足的进展。我们总结了在微观水平上提高生物研究效率的微流控技术。经过十年的研究，我们发现微流控与细胞生物学的全面整合以及微型细胞培养系统的开发为现场诊断和高通量药物筛选展现了巨大的前景。我们讨论了微流控细胞培养技术和方法的最新进展及其细胞生物学应用。我们为有兴趣为细胞生物学研究开发新颖、强大的微流体平台的研究人员提供一些见解和方向。 (C) 2012 Elsevier Ltd. 保留所有权利。
Microfluidics has developed as a powerful tool for cell-biology research due to its intrinsic advantages. Recently, considerable progress was made in microfluidic technology for cell culture and manipulation, and subsequent treatment and analysis.We summarize microfluidic technologies that improve the efficiency of biological research at the microscale level. From a decade of research, we find that the full integration of microfluidics with cell biology and the development of a microscale cell-culture system show great promise for point-of-care diagnostics and high-throughput drug screening.We discuss recent advances in technologies and methodologies in microfluidic cell culture and their cell-biology applications. We give some insights and directions for researchers interested in developing novel, robust microfluidic platforms for cell-biology research. (C) 2012 Elsevier Ltd. All rights reserved.