Guillain-Barre syndrome following influenza vaccination
Guillain-Barre syndrome following influenza vaccination
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DOI：
10.1001/jama.292.20.2478
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发表时间：
2004-11-24
影响因子：
120.7
通讯作者：
Chen, RT
中科院分区：
文献类型：
--
作者：
Haber, P;DeStefano, F;Chen, RT
背景1976-1977年，在接种猪流感疫苗的人群中，格林-巴利综合征（GBS）的风险出现了不明原因的增加。自1990年疫苗不良事件报告系统（VAERS）建立以来，格林-巴利综合征（Guillain-Barre syndrome，GBS）一直是流感疫苗接种后最常见的神经系统疾病。目的评价成人流感疫苗接种后GBS的报告趋势。从1990年7月1日至2003年6月30日，对每个流感季节18岁或以上人群接种流感疫苗后的GBS报告进行了评价。接种疫苗的人数是根据国家健康访谈调查和美国人口普查数据估计的。从1994年开始，积极的后续行动，以验证GBS的诊断，并获得其他临床details.Main结果测量报告率的GBS流感疫苗接种后随着时间的推移。结果从1990年7月至2003年6月，VAERS收到501报告GBS流感疫苗接种后的成人。流感疫苗接种后不良事件的中位发病间隔时间（13天）长于非GBS报告的中位发病间隔时间（1天）（P
Context An unexplained increase in the risk of Guillain-Barre syndrome (GBS) occurred among recipients of the swine influenza vaccine in 1976-1977. Guillain-Barre syndrome remains the most frequent neurological condition reported after influenza vaccination to the Vaccine Adverse Events Reporting System (VAERS) since its inception in 1990.Objective to evaluate trends of reports to VAERS of GBS following influenza vaccination in adults.Design, Setting, and Participants VAERS is the US national spontaneous reporting system for adverse events following vaccination. Reports of GBS in persons 18 years or older following influenza vaccination were evaluated for each influenza season from July 1, 1990, through June 30, 2003. The number of people vaccinated was estimated from the National Health Interview Survey and US census data. Beginning in 1994, active follow-up was conducted to verify GBS diagnosis and obtain other clinical details.Main Outcome Measure Reporting rates of GBS following influenza vaccination over time.Results From July 1990 through June 2003, VAERS received 501 reports of GBS following influenza vaccination in adults. The median onset interval (13 days) was longer than that of non-GBS reports of adverse events after influenza vaccine (1 day) (P