Rabbits and men: relating their ages
Rabbits and men: relating their ages
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DOI：
10.1515/jbcpp-2018-0002
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发表时间：
2018-09-01
影响因子：
--
通讯作者：
Sengupta, Pallav
中科院分区：
文献类型：
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作者：
Dutta, Sulagna;Sengupta, Pallav
兔是兔形目的成员，是与人类亲缘关系最近的动物，仅次于灵长类。就饲养、繁殖容易、成本效益和法律的伦理便利而言，它作为实验室哺乳动物比灵长类动物具有更大的可接受性。此外，作为实验动物，兔子在与人类的系统发育相似性、大小、血量、反应性和其他一致性方面也具有小鼠或大鼠的优势，使其能够在生物医学研究中更好地模仿人类的生理特征。一项特定的研究希望在特定的人类年龄组中实现其结果，为此，选择一只准确年龄的实验室兔子至关重要，这将与人类的特定年龄相关联，目前仅基于近似值。这篇文章是有史以来第一次科学冒险，重点是通过将实验室兔子年龄的近似值与人类分别分析生命的不同阶段的年龄相关联来准确地交换。考虑到兔子的寿命与人类相比很短，它们的年龄与整个寿命的相关性，我们发现与人类的一年相比，它们的年龄为45.625天，这是不够的。因此，就像我们以前的文章一样，制定了实验室大鼠和小鼠年龄与人类年龄的简明关系，在这篇文章中，我们的目标也是帮助生物医学研究在选择实验室模型年龄时的特异性，分别将人类的不同生命阶段与兔子相关联，兔子是2016年美国第二大使用的哺乳动物。
Rabbit, a member of the Lagomorpha order, is the closest phylogenetic relative to humans, next to primates. It possesses greater acceptability as a laboratory mammal than primates in terms of husbandry, breeding ease, cost effectiveness, and legal ethical conveniences. Moreover, as a laboratory animal, the rabbit also owns its advantages over mice or rats, in terms of phylogenetic resemblance to human, size, blood volume, responsiveness, and other congruences enabling them to better imitate human physiological characteristics in biomedical research. A specific research aspires to effectuate its outcome on a particular human age group, for which it is pivotal to select a laboratory rabbit of exact age, which will correlate with that specific age of a human, which is currently based on mere approximation. This article is the first ever scientific venture, focused to swap this approximation of laboratory rabbit age with accuracy by relating it with that of humans analyzing different phases of life individually. Considering the diminutive lifespan of rabbits compared to humans, the correlation of their age with respect to the entire lifespan, which we found out to be 45.625 days compared to one human year, is not enough. Thereby, like our previous articles that formulated concise relation of age of laboratory rats and mice with human age, in this article also, we aim to aid biomedical research specificity in the selection of laboratory model age, separately correlating different life phases of humans with that of rabbits, the second mostly used mammal in 2016 in the United States.