An infant with recurrent convulsive seizures of 3 weeks duration: Questions
An infant with recurrent convulsive seizures of 3 weeks duration: Questions
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DOI：
10.1007/s00467-013-2615-4
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发表时间：
2014-10
影响因子：
3
通讯作者：
M. Shimizu;Y. Niida;S. Koizumi;A. Yachie
中科院分区：
文献类型：
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作者：
M. Shimizu;Y. Niida;S. Koizumi;A. Yachie
一名1个月大的日本男孩入院，有持续3周的反复惊厥发作史。他在一次顺利的妊娠后足月出生（妊娠40周），出生体重正常，为2.76 kg。他是健康父母的第一个孩子，没有血缘关系。婴儿在出生后第14天出现惊厥性癫痫发作之前情况良好。入院时，医生观察到强直性表现，如腕足痉挛和惊厥性癫痫发作。患者的血清钙水平为5.0 mg/dL（正常范围8.0-10.5 mg/dL），无机磷酸盐水平为6.2 mg/dL（正常范围2.5-4.5 mg/dL）。肌肉注射高剂量葡萄糖酸钙和甲状旁腺激素（PTH），但强直性惊厥未消退。当时，测量血清镁水平，发现极低，为0.16 mEq/L（正常范围1.44-1.81 mEq/L）。镁的尿排泄量也较低，为0.13 mEq/天（正常值为0.31 mEq/L）。
A 1-month-old Japanese boy was admitted to the hospital with a history of recurrent convulsive seizures of 3 weeks in duration. He was born at term (40 week gestation) at a normal birth weight of 2.76 kg following an uneventful pregnancy. He was the first child of healthy parents; there was no history of consanguinity. The infant was well until the 14th day of life when he developed convulsive seizures. On admission, the physicians observed tetanic manifestations, such as carpopedal spasms and convulsive seizures. The patient’s serum calcium level was 5.0 mg/dL (normal range 8.0–10.5 mg/dL), and the inorganic phosphate level was 6.2 mg/dL (normal range 2.5–4.5 mg/dL). Calcium gluconate and parathyroid hormone (PTH) were administered intramuscularly in high doses, but the tetanic convulsions did not resolve. At that time, the serum magnesium level was measured and found to be extremely low at 0.16 mEq/L (normal range 1.44–1.81 mEq/L). The urinary excretion of magnesium was also low at 0.13 mEq/day (normal 0.31 mEq/L).