The cAMP-dependent protein kinase signaling pathway is a key regulator of P body foci formation.
The cAMP-dependent protein kinase signaling pathway is a key regulator of P body foci formation.
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DOI：
10.1016/j.molcel.2011.06.032
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发表时间：
2011-09-16
期刊：
影响因子：
16
通讯作者：
Herman PK
中科院分区：
文献类型：
--
作者：
Ramachandran V;Shah KH;Herman PK
In response to stress, eukaryotic cells accumulate mRNAs and proteins at discrete sites, or foci, in the cytoplasm. However, the mechanisms regulating foci formation, and the biological function of the larger ribonucleoprotein (RNP) assemblies, remain poorly understood. Here, we show that the cAMP-dependent protein kinase (PKA) in Saccharomyces cerevisiae is a key regulator of the assembly of Processing-bodies (P-bodies), an RNP complex implicated in mRNA processing and translation. The data suggest that PKA specifically inhibits the formation of the larger P-body aggregates by directly phosphorylating Pat1, a conserved constituent of these foci that functions as a scaffold during the assembly process. Finally, we present evidence indicating that P-body foci are required for the long-term survival of stationary phase cells. This work therefore highlights the general relevance of RNP foci in quiescent cells, and provides a framework for the study of the many RNP assemblies that form in eukaryotic cells.
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影响因子：
11.4
作者：
Braun, Joerg E.;Tritschler, Felix;Haas, Gabrielle;Igreja, Catia;Truffault, Vincent;Weichenrieder, Oliver;Izaurralde, Elisa
通讯作者：
Izaurralde, Elisa
影响因子：
7.8
作者：
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通讯作者：
Parker, Roy
DOI：
10.1083/jcb.136.4.761
发表时间：
1997-02-24
期刊：
The Journal of cell biology
影响因子：
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作者：
Bashkirov VI;Scherthan H;Solinger JA;Buerstedde JM;Heyer WD
通讯作者：
Heyer WD
DOI：
10.1073/pnas.0607084104
发表时间：
2007-02-13
影响因子：
11.1
作者：
Chi, An;Huttenhower, Curtis;Hunt, Donald F.
通讯作者：
Hunt, Donald F.
影响因子：
3.3
作者：
Deminoff, Stephen J.;Ramachandran, Vidhya;Herman, Paul K.
通讯作者：
Herman, Paul K.