In vivo heat-stimulus-triggered osteogenesis
In vivo heat-stimulus-triggered osteogenesis
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DOI：
10.3109/02656736.2014.988662
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发表时间：
2015-02-01
影响因子：
3.1
通讯作者：
Nishida, Yoshihiro
中科院分区：
文献类型：
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作者：
Ikuta, Kunihiro;Urakawa, Hiroshi;Nishida, Yoshihiro
几项研究报告称，热应激会刺激体外成骨细胞的活性。然而，很少有人研究热应激对体内成骨的影响，也没有确定骨形成的最佳温度。本研究的目的是研究热疗治疗对大鼠胫骨缺损模型中成骨的影响。将四十四只 Sprague Dawley 大鼠分为两组，进行或不进行热疗治疗。胫骨近端的 3 毫米圆形缺损填充有嵌入海藻酸盐珠中的磁铁矿阳离子脂质体，并进行热疗（43-46 摄氏度）。治疗后两周的放射学评估显示，与对照组相比，热疗组观察到显着刺激的成骨作用（p = 0.003）。两周时的组织形态计量学分析显示，与对照组相比，热疗组新形成的骨显着增加（p
Several studies have reported that heat stress stimulates the activity of osteoblastic cells in vitro. However, few have addressed the effects of heat stress on osteogenesis in vivo, nor have the optimal temperatures for bone formation been determined. The aim of the present study was to investigate the effects of hyperthermia treatment on osteogenesis in a rat tibial defect model. Forty-four Sprague Dawley rats were divided into two groups with or without hyperthermia treatment. A 3-mm circular defect in the proximal tibia filled with magnetite cationic liposomes embedded in alginate beads was subjected to hyperthermia treatment (43-46 degrees C). Radiological assessment at 2 weeks after the treatment showed that significantly stimulated osteogenesis was observed in the hyperthermia group as compared to the control group (p = 0.003). Histomorphometrical analysis at 2 weeks revealed a significant increase of newly formed bone in the hyperthermia group, compared with the control group (p