Methylprednisolone reduces the inflammatory response to cardiopulmonary bypass in neonatal piglets: Timing of dose is important
Methylprednisolone reduces the inflammatory response to cardiopulmonary bypass in neonatal piglets: Timing of dose is important
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DOI：
10.1016/s0022-5223(99)70331-4
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发表时间：
1999-03-01
影响因子：
6
通讯作者：
Jaggers, J
中科院分区：
文献类型：
--
作者：
Lodge, AJ;Chai, PJ;Jaggers, J
导言：体外循环会产生炎症反应，可导致严重的术后肺功能障碍和全身浮肿。本研究评估了术前给予甲基强的松龙在限制新生儿这种损伤方面的效果，并将术前8小时给予甲基强的松龙的效果与将甲基强的松龙加入体外循环回路的常见做法进行了比较。方法：新生猪对照组(对照组，n=6)，术前不给药。实验组(n=6)术前8h和1.5h同时给予甲基强的松龙琥珀酸钠(30 mg/kg)。第二个实验组不接受术前治疗，但在体外循环循环基础上加入甲基强的松龙(30 mg/kg)。所有动物均接受体外循环和45分钟深低温停循环。分别于体外循环前、转流后30分钟和60分钟采集血流动力学和肺功能数据。结果：对照组转流后肺顺应性、肺泡-动脉压差、肺血管阻力明显受损(P
Introduction: Cardiopulmonary bypass produces an inflammatory response that can cause significant postoperative pulmonary dysfunction and total body edema. This study evaluates the efficacy of preoperative methylprednisolone administration in limiting this injury in neonates and compares the effect of giving methylprednisolone 8 hours before an operation to the common practice of adding methylprednisolone to the cardiopulmonary bypass circuit prime. Methods: A control group of neonatal pigs (control; n = 6) received no preoperative medication. One experimental group (n = 6) received methylprednisolone sodium succinate (30 mg/kg) both 8 and 1.5 hours before the operation. A second experimental group received no preoperative treatment, but methylprednisolone (30 mg/kg) was added to the cardiopulmonary bypass circuit prime. All animals underwent cardiopulmonary bypass and 45 minutes of deep hypothermic circulatory arrest. Hemodynamic and pulmonary function data were acquired before cardiopulmonary bypass and at 30 and 60 minutes after bypass. Results: In the control group, pulmonary compliance, alveolar-arterial gradient, and pulmonary vascular resistance were significantly impaired after bypass (P