Direct contribution of vascular mineralocorticoid receptors to blood pressure regulation.
Direct contribution of vascular mineralocorticoid receptors to blood pressure regulation.
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DOI：
10.1111/1440-1681.12125
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发表时间：
2013-12
影响因子：
2.9
通讯作者：
Jaffe IZ
中科院分区：
文献类型：
--
作者：
Barrett KV;McCurley AT;Jaffe IZ
高血压是一种非常普遍的心血管危险因素，目前的抗高血压治疗不能充分治疗许多受影响的个体的高血压。因此，更好地了解高血压的机制可能会导致新的治疗方法。已知盐皮质激素受体（MR）通过响应肾脏中的醛固酮调节钠潴留来调节血压。最近的证据支持的直接贡献的血管控制BP和MR拮抗剂也可能通过作用于肾外MR降低血压的可能性。本文综述了现有的研究考虑的作用，血管盐皮质激素受体（MR）在调节血管反应性和血压。多项研究表明血管MR在调节血管收缩和血管舒张中的作用。血管内皮细胞和平滑肌细胞中MR的激活导致活性氧产生增加和一氧化氮（血管反应性的重要调节剂）的可用性降低。转基因小鼠模型，包括内皮MR过表达小鼠和平滑肌细胞特异性MR敲除小鼠，支持血管MR在控制血压中的直接作用。这一新证据表明，血管MR直接有助于控制血管反应性和血压，支持血管MR及其控制的途径作为治疗高血压的新治疗靶点。
Hypertension is an extremely prevalent cardiovascular risk factor and current antihypertensive therapies do not adequately treat hypertension in many affected individuals. Thus a better understanding of mechanisms of hypertension could lead to novel therapies. Mineralocorticoid receptors (MR) are known to regulate blood pressure by responding to aldosterone in the kidney to regulate sodium retention. Recent evidence supports a direct contribution of the vasculature to control of BP and suggests the possibility that MR antagonists may also lower blood pressure by acting on extra-renal MR. This review summarizes existing research considering the role of vascular mineralocorticoid receptor (MR) in regulating vasoreactivity and blood pressure. Multiple studies indicate a role for vascular MR in modulating vasoconstriction and vasorelaxation. Activation of MR in vascular endothelial and smooth muscle cells leads to increased reactive oxygen species production and decreased availability of nitric oxide, important regulators of vascular reactivity. Transgenic mouse models, including an endothelial MR over-expressing mouse and a smooth muscle cell-specific MR knockout mouse, support a direct role for vascular MR in control of blood pressure. This new evidence demonstrating that vascular MR directly contributes to control of vasoreactivity and blood pressure supports vascular MR, and the pathways it controls, as novel therapeutic targets to treat hypertension.
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影响因子：
4.8
作者：
GarciaCardena, G;Fan, R;Sessa, WC
通讯作者：
Sessa, WC
影响因子：
8.3
作者：
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通讯作者：
Webb, RC
DOI：
10.1046/j.1440-1681.2001.03566.x
发表时间：
2001-12-01
影响因子：
2.9
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影响因子：
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作者：
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通讯作者：
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