The impact of methods for estimating bone health and the global burden of bone disease.
The impact of methods for estimating bone health and the global burden of bone disease.
复制标题
评估骨骼健康方法的影响和骨骼疾病的全球负担。
DOI：
10.1590/s0036-36342009000700007
复制
发表时间：
2009
影响因子：
2.3
通讯作者：
C. Cooper
中科院分区：
文献类型：
--
作者：
Z. Cole;E. Dennison;C. Cooper
骨质疏松症通过其与年龄相关的骨折的关联而构成主要的公共卫生问题。高加索妇女的骨折率通常高于其他人群。重要的决定因素包括妇女雌激素缺乏、体重指数低、吸烟、饮酒、膳食钙摄入量不足、缺乏运动、某些药物和疾病。因此，改变体力活动和膳食钙/维生素D营养应补充高风险的方法。此外，最近开发的世卫组织10年绝对骨折风险评估算法提供了一种手段，使各种治疗方法能够以具有成本效益的方式针对风险人群。风险因素，以及骨矿物质密度（BMD）和骨转换的生化指标，可用于推导骨折的绝对风险和治疗合理的成本效用阈值。这些数据将为转化为旨在预防个人和一般人群骨质疏松症的连贯公共卫生战略提供基础。
Osteoporosis constitutes a major public health problem through its association with age related fractures. Fracture rates are generally higher in caucasian women than in other populations. Important determinants include estrogen deficiency in women, low body mass index, cigarette smoking, alcohol consumption, poor dietary calcium intake, physical inactivity, certain drugs and illnesses. Thus, modification of physical activity and dietary calcium/vitamin D nutrition should complement high risk approaches. In addition, the recently developed WHO algorithm for evaluation of 10-year absolute risk of fracture provides a means whereby various therapies can be targeted cost-effectively to those at risk. Risk factors, together with bone mineral density (BMD) and biochemical indices of bone turnover, can be utilised to derive absolute risks of fracture and cost-utility thresholds at which treatment is justified. These data will provide the basis for translation into coherent public health strategies aiming to prevent osteoporosis both in individuals and in the general population.