canSAR: update to the cancer translational research and drug discovery knowledgebase
canSAR: update to the cancer translational research and drug discovery knowledgebase
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DOI：
10.1093/nar/gky1129
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发表时间：
2019-01-08
影响因子：
14.9
通讯作者：
Al-Lazikani, Bissan
中科院分区：
文献类型：
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作者：
Coker, Elizabeth A.;Mitsopoulos, Costas;Al-Lazikani, Bissan
canSAR（cansar.icr.ac.uk）是一个公共的、免费的、综合性转化研究和药物发现知识库。canSAR帮助研究人员解决癌症转化和药物发现的关键瓶颈。它将基因组、蛋白质、药理学、药物和化学数据与结构生物学、蛋白质网络和独特、全面和正交的可药用性评估相结合。canSAR在国际上被学术界和工业界广泛使用。在这里，我们描述了canSAR的主要增强功能，包括新的和扩展的数据。我们还介绍了canSARblackan的第一个组件，这是一个先进的、响应迅速的、多设备兼容的canSAR重新设计，具有以问题为导向的界面。
canSAR (http://cansar.icr.ac.uk) is a public, freely available, integrative translational research and drug discovery knowlegebase. canSAR informs researchers to help solve key bottlenecks in cancer translation and drug discovery. It integrates genomic, protein, pharmacological, drug and chemical data with structural biology, protein networks and unique, comprehensive and orthogonal druggability' assessments. canSAR is widely used internationally by academia and industry. Here we describe major enhancements to canSAR including new and expanded data. We also describe the first components of canSARblackan advanced, responsive, multi-device compatible redesign of canSAR with a question-led interface.