Simultaneous Determination of 5 Active Components of Periploca forrestii Schltr Extract in Rat Plasma by UPLC-MS and Its Application to Pharmacokinetic Studies in Normal and Adjuvant-Induced Arthritis Model Rats
Simultaneous Determination of 5 Active Components of Periploca forrestii Schltr Extract in Rat Plasma by UPLC-MS and Its Application to Pharmacokinetic Studies in Normal and Adjuvant-Induced Arthritis Model Rats
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UPLC-MS同时测定大鼠血浆中杠柳提取物中的5种活性成分及其在正常和佐剂性关节炎模型大鼠药代动力学研究中的应用
DOI：
10.1177/1934578x20981435
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发表时间：
2020-12
影响因子：
1.8
通讯作者：
Yong Huang
中科院分区：
文献类型：
--
作者：
Hui Liu;Hao Chen;Xiaoli Qin;Xue Ma;Zipeng Gong;Yueting Li;Siying Chen;Jie Pan;Aimin Wang;Lin Zheng;Yong Huang
杠柳（Periploca forrestii Schltr）是一种中药，具有抗类风湿关节炎的作用。本研究的目的是比较该植物的5种活性成分：新绿原酸，绿原酸，隐绿原酸，异绿原酸C，杠柳毒苷在正常大鼠和关节炎模型大鼠之间的药代动力学特性。在静脉给予（177.78 mg/kg）黑木耳提取物后，通过超高效液相色谱-串联质谱法分析样品。与正常大鼠相比，新绿原酸治疗组大鼠的曲线下面积[AUC（0-t），AUC（0-∞）]、平均滞留时间[MRT（0-t），MRT（0-∞）]显著降低，药物清除率（CL）和表观分布容积（V）显著增加;绿原酸治疗组大鼠的V显著降低，MRT（0-t）显著增加;隐绿原酸组AUC（0-t）、AUC（0-∞）显著降低，CL、V显著升高，异绿原酸C组AUC（0-t）、MRT（0-t）显著降低，V显著升高;杠柳毒苷组AUC（0-t）、AUC（0-∞）显著升高，模型组MRT（0-t）、MRT（0-∞）、CL、V显著降低。类风湿性关节炎大鼠的病情对经静脉给药后的黑木耳体内药代动力学有显著影响。
Periploca forrestii Schltr (P. forrestii) is a herb used in traditional Chinese medicine for its anti-rheumatoid arthritis effect. The aim of this study was to compare the pharmacokinetic properties of the 5 active components of this plant: neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid, isochlorogenic acid C, and periplocin between normal rats and adjuvant-induced arthritis model rats. After the intravenous administration (177.78 mg/kg) of P. forrestii extract, samples were analyzed by ultra-performance liquid chromatography-tandem mass spectrometry. Compared with normal rats, the area under the curve [(AUC)(0-t), AUC(0-∞)], mean residence time [(MRT)(0-t), MRT(0-∞)] of neochlorogenic acid-treated rats decreased significantly, and drug clearance (CL) and apparent volume of distribution (V) increased significantly; the V of chlorogenic acid-treated rats decreased significantly, and MRT(0-t) significantly increased; the AUC(0-t) and AUC(0-∞) of cryptochlorogenic acid-treated rats decreased significantly, and CL and V increased significantly; the AUC(0-t) and MRT(0-t) of isochlorogenic acid C-treated rats decreased significantly, and V increased significantly; the AUC(0-t) and AUC(0-∞) of periplocin-treated rats increased significantly, and MRT(0-t), MRT(0-∞), CL, and V decreased significantly in model rats. The disease condition of rheumatoid arthritis in rats had a significant effect on the in vivo pharmacokinetics of P. forrestii after the intravenous administration.
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