Differences in clinical manifestations among Cryptosporidium species and subtypes in HIV-infected persons
Differences in clinical manifestations among Cryptosporidium species and subtypes in HIV-infected persons
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DOI：
10.1086/519842
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发表时间：
2007-09-01
影响因子：
6.4
通讯作者：
Xiao, Lihua
中科院分区：
文献类型：
--
作者：
Cama, Vitaliano A.;Ross, Jennifer M.;Xiao, Lihua
我们进行了一项横断面研究，以确定人类免疫缺陷病毒 (HIV) 感染者中隐孢子虫的流行病学，并在 3 个诊断水平上进行：显微镜检查、隐孢子虫基因型以及人隐孢子虫和小隐孢子虫亚型家族。该研究在秘鲁利马招募了 2490 名 HIV 感染者，其中 230 名隐孢子虫感染显微镜检查呈阳性。 193 名参与者的样本可用于基因分型。他们感染了人念珠菌（141人）、小念珠菌（22人）、黑念珠菌（17人）、犬念珠菌（6人）、猫念珠菌（6人）和猪念珠菌（1人）。尽管显微镜检查结果显示隐孢子虫感染与腹泻相关，但只有犬隐孢子虫、猫隐孢子虫和人隐孢子虫亚型家族 Id 的感染与腹泻相关，而小隐孢子虫感染与慢性腹泻和呕吐相关。这些结果表明，不同的隐孢子虫基因型和亚型家族与不同的临床表现相关。
We performed a cross-sectional study to determine the epidemiology of Cryptosporidium in human immunodeficiency virus (HIV)-infected persons at 3 diagnostic levels: microscopy, genotypes of Cryptosporidium, and subtype families of C. hominis and C. parvum. The study enrolled 2490 HIV-infected persons in Lima, Peru, and 230 were microscopy positive for Cryptosporidium infection. Specimens from 193 participants were available for genotyping. They had C. hominis (141 persons), C. parvum (22 persons), C. meleagridis (17 persons), C. canis (6 persons), C. felis (6 persons), and C. suis (1 person) infection. Although microscopy results showed that Cryptosporidium infections were associated with diarrhea, only infections with C. canis, C. felis, and subtype family Id of C. hominis were associated with diarrhea, and infection with C. parvum was associated with chronic diarrhea and vomiting. These results demonstrate that different Cryptosporidium genotypes and subtype families are linked to different clinical manifestations.