Reduced prefrontal gray matter volume and reduced autonomic activity in antisocial personality disorder
Reduced prefrontal gray matter volume and reduced autonomic activity in antisocial personality disorder
复制标题
DOI：
10.1001/archpsyc.57.2.119
复制
发表时间：
2000-02-01
影响因子：
--
通讯作者：
Colletti, P
中科院分区：
文献类型：
--
作者：
Raine, A;Lencz, T;Colletti, P
背景：已经发现前额叶皮层灰质和白质的严重损伤和自主神经缺陷导致神经系统疾病患者的伪精神病人格，但尚不清楚社区中没有明显脑外伤的反社会人格障碍（APD）患者是否也有轻微的前额叶缺陷。方法：采用结构磁共振成像技术对21例社区志愿者APD患者（APD组）和2个对照组（健康组34例，物质依赖组26例，精神对照组21例）的前额叶灰质和白质体积进行评估。在一个社会压力测试中，研究人员还对参与者的自主神经活动（皮肤电导和心率）进行了评估。结果：APD组在无明显脑损伤的情况下，前额叶灰质体积减少11.0%，应激时自主神经活动减少。这些缺陷预测了独立于社会心理风险因素的群体成员资格。结论：据我们所知，这些发现为APD的结构性脑缺陷提供了第一个证据。这种前额叶结构缺陷可能是低觉醒、糟糕的恐惧条件反射、缺乏良知和决策缺陷的基础，这些都是反社会、精神病行为的特征。
Background: Major damage to gray and white matter in the prefrontal cortex and autonomic deficits have been found to result in pseudopsychopathic personality in patients with neurological disorders, but it is not known whether people with antisocial personality disorder (APD) in the community who do not have discernable brain trauma also have subtle prefrontal deficits.Methods: Prefrontal gray and white matter volumes were assessed using structural magnetic resonance imaging in 21 community volunteers with APD (APD group) and in 2 control groups, comprising 34 healthy subjects (control group), 26 subjects with substance dependence (substance-dependent group), and 21 psychiatric controls. Autonomic activity (skin conductance and heart rate) was also assessed during a social stresser in which participants gave a videotaped speech on their faults.Results: The APD group showed an 11.0% reduction in prefrontal gray matter volume in the absence of ostensible brain lesions and reduced autonomic activity during the stresser. These deficits predicted group membership independent of psychosocial risk factors.Conclusions: To our knowledge, these findings provide the first evidence for a structural brain deficit in APD. This prefrontal structural deficit may underlie the low arousal, poor fear conditioning, lack of conscience, and decision-making deficits that have been found to char acterize antisocial, psychopathic behavior.