B-cell function and islet cell and other organ-specific autoantibodies in relatives to insulin-dependent diabetic patients.
B-cell function and islet cell and other organ-specific autoantibodies in relatives to insulin-dependent diabetic patients.
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胰岛素依赖型糖尿病患者亲属的 B 细胞功能以及胰岛细胞和其他器官特异性自身抗体。
DOI：
10.1111/j.0954-6820.1983.tb03717.x
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发表时间：
1983
影响因子：
--
通讯作者：
Lernmark,A
中科院分区：
文献类型：
--
作者：
Nordén,G;Jensen,E;Stilbo,I;Bottazzo,GF;Lernmark,A
研究了45例30岁前诊断为胰岛素依赖型糖尿病患者的一级亲属的胰腺B细胞功能（葡萄糖耐量，C肽释放）和器官特异性自身抗体，包括胰岛细胞细胞质和细胞表面（小鼠）。与107名无胰岛素依赖型或非胰岛素依赖型糖尿病家族史的健康人相比，亲属中自身抗体的患病率增加。胰岛细胞抗体的患病率在亲属和对照组之间没有差异，并且没有个体具有补体固定的胰岛细胞抗体。无论是否有自身抗体，亲属和对照组之间的葡萄糖耐量和C肽释放量没有差异。在三年的随访中，没有一个人患上胰岛素依赖型糖尿病。
The pancreatic B‐cell function (glucose tolerance, C‐peptide release) and organ‐specific autoantibodies, including islet cell cytoplasmic and cell surface (mouse), were studied in 45 first‐degree relatives of patients with insulin‐dependent diabetes mellitus diagnosed before the age of 30 years. Compared to 107 healthy persons without any family history of either insulin‐dependent or non‐insulin‐dependent diabetes mellitus, the prevalence of autoantibodies was increased among the relatives. The prevalence of islet cell antibodies did not differ between relatives and controls and none of the individuals had complement‐fixing islet cell antibodies. There was no difference in glucose tolerance or C‐peptide release between relatives and controls, whether they had autoantibodies or not. At a three‐year follow‐up, none of the individuals had developed insulin‐dependent diabetes.