Chronic activity-based therapy does not improve body composition, insulin-like growth factor-I, adiponectin, or myostatin in persons with spinal cord injury
Chronic activity-based therapy does not improve body composition, insulin-like growth factor-I, adiponectin, or myostatin in persons with spinal cord injury
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DOI：
10.1179/2045772314y.0000000236
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发表时间：
2015-09-01
影响因子：
1.7
通讯作者：
Witzke, Kara A.
中科院分区：
文献类型：
--
作者：
Astorino, Todd A.;Harness, Eric T.;Witzke, Kara A.
脊髓损伤（SCI）引起机体成分的剧烈变化，包括无脂量（FFM）的减少和脂肪量（FM）的增加。目的：探讨慢性活动疗法（ABT）对脊髓损伤患者身体成分的影响。设计：纵向运动干预。方法：17名SCI患者（平均年龄= 36.1±11.5岁）完成了6个月的ABT训练，包括负重训练、阻力训练、运动训练和功能性电刺激。在基线和ABT治疗3个月和6个月后，使用双能x线吸收仪评估体重、体脂和FFM，并获得空腹血液样本以评估胰岛素样生长因子- i （IGF-I）、脂联素和肌肉生长抑制素的变化。结果：在所有受试者中，体重、体脂百分比或腿部、手臂或躯干的FFM没有变化（P > 0.05），而全身FFM下降（P = 0.02, 50.4 +/- 8.4至49.2 +/- 7.4 kg）。在研究期间，igf - 1、脂联素或肌肉生长抑制素没有变化（P = 0.21-0.41）。结论：专注于下肢的慢性ABT不能减缓脊髓损伤患者的肌肉萎缩或改变体脂、体质量或FFM的区域分布。此外，它不会诱导脂联素、肌肉生长抑制素或igf - 1的有益变化。脊髓损伤需要以运动为基础的替代疗法来逆转肌肉萎缩，并将相关健康风险降至最低。
Spinal cord injury (SCI) induces dramatic changes in body composition including reductions in fat-free mass (FFM) and increases in fat mass (FM).Objective: To examine changes in body composition in response to chronic activity-based therapy (ABT) in persons with SCI.Design: Longitudinal exercise intervention.Methods: Seventeen men and women with SCI (mean age = 36.1 +/- 11.5 years) completed 6 months of supervised ABT consisting of load bearing, resistance training, locomotor training, and functional electrical stimulation. At baseline and after 3 and 6 months of ABT, body weight, body fat, and FFM were assessed using dual-energy X-ray absorptiometry, and fasting blood samples were obtained to assess changes in insulin-like growth factor-I (IGF-I), adiponectin, and myostatin.Results: Across all subjects, there was no change (P > 0.05) in body weight, percent body fat, or FFM of the leg, arm, or trunk, whereas whole-body FFM declined (P = 0.02, 50.4 +/- 8.4 to 49.2 +/- 7.4 kg). No changes (P = 0.21-0.41) were demonstrated in IGF-I, adiponectin, or myostatin during the study.Conclusions: Chronic ABT focusing on the lower extremity does not slow muscle atrophy or alter body fat, body mass, or regional depots of FFM in persons with SCI. Further, it does not induce beneficial changes in adiponectin, myostatin, or IGF-I. Alternative exercise-based therapies are needed in SCI to reverse muscle atrophy and minimize the onset of related health risks.