Resveratrol attenuates microvascular inflammation in sepsis via SIRT-1-Induced modulation of adhesion molecules in ob/ob mice.
Resveratrol attenuates microvascular inflammation in sepsis via SIRT-1-Induced modulation of adhesion molecules in ob/ob mice.
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DOI：
10.1002/oby.21086
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发表时间：
2015-06
期刊：
影响因子：
--
通讯作者：
Vachharajani VT
中科院分区：
文献类型：
--
作者：
Wang X;Buechler NL;Yoza BK;McCall CE;Vachharajani VT
Obesity, a Sirtuin-1 (SIRT-1) deficient state, increases morbidity and resource utilization in critically ill patients. SIRT-1 deficiency increases microvascular inflammation and mortality in early sepsis. Our objective was to study the effect of resveratrol (RSV), a SIRT-1 activator, on microvascular inflammation in obese septic mice. ob/ob and C57Bl/6 (WT) mice were pre-treated with RSV vs. DMSO (Vehicle) prior to cecal ligation and puncture (Sepsis). We studied 1) Leukocyte/Platelet adhesion 2) E-selectin, ICAM-1 and SIRT-1 expression in small intestines 3) 7-day survival. A group of RSV treated mice received SIRT-1 inhibitor (EX-527) with sepsis-induction and leukocyte/platelet adhesion and E-selectin/ICAM-1 expression were studied. We treated endothelial (HUVEC) cells with RSV to study E-selectin/ICAM-1 and p65-acetylation (AC-p65) in response to LPS. RSV treatment decreased leukocyte/platelet adhesion and E-selectin/ICAM-1 expression with increased SIRT1 expression in septic ob/ob and WT mice; decreased E-Selectin/ICAM-1 expression via increased SIRT-1 expression and decreased AC-p65 expression in HUVEC. EX-527 abolished RSV-induced attenuation of microvascular inflammation in ob/ob septic mice. Finally, ob/ob mice in Sepsis+RSV group had significantly increased 7-day survival vs. Sepsis+Vehicle group. RSV increases SIRT-1 expression in ob/ob-septic mice to reduce microvascular inflammation and improves survival.
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影响因子：
3.2
作者：
Liu, L. Q.;Fan, Z. Q.;Ke, Z. J.
通讯作者：
Ke, Z. J.
影响因子：
4.8
作者：
Liu, Tie Fu;Yoza, Barbara K.;Mccall, Charles E.
通讯作者：
Mccall, Charles E.
DOI：
10.1161/01.atv.0000056742.97580.79
发表时间：
2003-04-01
影响因子：
8.7
作者：
Tailor, A;Granger, DN
通讯作者：
Granger, DN
影响因子：
4.8
作者：
Liu, Tie Fu;Vachharajani, Vidula T.;McCall, Charles E.
通讯作者：
McCall, Charles E.
影响因子：
15.9
作者：
Jung, U;Norman, KE;Ley, K
通讯作者：
Ley, K