The intramolecular, stereoselective addition of sulfoximine carbanions to α,β-unsaturated esters
The intramolecular, stereoselective addition of sulfoximine carbanions to α,β-unsaturated esters
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DOI：
10.1021/ja034744z
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发表时间：
2003-05-14
影响因子：
15
通讯作者：
Hong, XC
中科院分区：
文献类型：
--
作者：
Harmata, M;Hong, XC
邻溴肉桂酸酯可以与甲基苯基亚砜亚胺偶联，以优异的收率得到 N-芳基亚砜亚胺。用酰胺碱处理这些产物导致完全立体选择性环化，得到对映体纯的苯并噻嗪。该反应是立体定向的。
ortho-Bromocinnamates can be coupled with methyl phenylsulfoximine to afford N-arylsulfoximines in excellent yield. Treatment of these products with an amide base results in a completely stereoselective cyclization to afford enantiomerically pure benzothiazines. This reaction is stereospecific.