Associations of prenatal or infant exposure to acetaminophen or ibuprofen with mid-childhood executive function and behaviour
Associations of prenatal or infant exposure to acetaminophen or ibuprofen with mid-childhood executive function and behaviour
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DOI：
10.1111/ppe.12596
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发表时间：
2019-10-21
影响因子：
2.8
通讯作者：
Oken, Emily
中科院分区：
文献类型：
--
作者：
Rifas-Shiman, Sheryl L.;Cardenas, Andres;Oken, Emily
背景 妊娠期或婴儿期的非处方镇痛药可能与儿童的神经行为问题有关，但人们对不同镇痛药类型、剂量和时间的影响知之甚少。目的 检查妊娠期和婴儿期使用对乙酰氨基酚和布洛芬与儿童执行功能和行为问题的关系。方法 我们纳入了来自 Project Viva（一项产前队列研究）的 1225 对母子。我们使用问卷调查评估了妊娠早期和中期的产前对乙酰氨基酚和布洛芬的使用情况以及婴儿出生第一年的使用情况。家长和课堂教师使用执行功能行为评定量表 (BRIEF) 和优势与困难问卷 (SDQ) 评估儿童中期（中位 8 岁）的行为，分数越高表明两者的功能越差。我们使用针对潜在混杂因素进行调整的线性回归模型，研究了妊娠期和婴儿期使用对乙酰氨基酚和布洛芬与儿童中期神经行为结果的关联。结果 怀孕期间，46.1% 的母亲使用对乙酰氨基酚≥10 次，18.4% 的母亲使用过布洛芬。在第一年，65.3% 和 39.6% 的婴儿分别接受了对乙酰氨基酚和布洛芬≥6 次的治疗。更高 (>= 10 vs = 6 vs
Background Over-the-counter analgesics during pregnancy or infancy may be related to neurobehavioural problems in children, but little is known about effects of different analgesic types, dosage, and timing. Objectives Examine associations of acetaminophen and ibuprofen use during pregnancy and infancy with executive function and behaviour problems in children. Methods We included 1225 mother-child pairs from Project Viva, a pre-birth cohort study. We assessed prenatal acetaminophen and ibuprofen use in early and mid-pregnancy and infant use in the first year of life using questionnaires. Parents and classroom teachers assessed child behaviours in mid-childhood (median 8 years), using the Behavior Rating Inventory of Executive Function (BRIEF) and the Strengths and Difficulties Questionnaire (SDQ), with higher scores indicating worse functioning for both. We examined associations of acetaminophen and ibuprofen use during pregnancy and infancy with mid-childhood neurobehavioural outcomes using linear regression models adjusted for potential confounders. Results During pregnancy, 46.1% of mothers used acetaminophen >= 10 times and 18.4% used any ibuprofen. In the first year, 65.3% and 39.6% of infants received acetaminophen and ibuprofen >= 6 times, respectively. Higher (>= 10 vs = 6 vs