Pulmonary vascular reactivity and permeability to alveolar hypoxia in the dog.
Pulmonary vascular reactivity and permeability to alveolar hypoxia in the dog.
复制标题
狗的肺血管反应性和对肺泡缺氧的渗透性。
DOI：
10.1152/jappl.1990.69.5.1828
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Ehrhart,IC
中科院分区：
文献类型：
--
作者：
Hofman,WF;Ehrhart,IC
本文研究了犬离体肺在急性肺泡低氧状态下的血流动力学和血管通透性。用消炎痛或甲氯芬酯抑制环氧合酶(COI)诱导缺氧。低氧通气使血氧分压从143降至25-29托，而二氧化碳分压没有变化。在低氧条件下，用重量法测得毛细血管过滤系数(KF)，作为血管对水的通透性指标。在COI+Hypox组，肺动脉压(Pa值)从COI常氧后的11.5+/-0.7上升到低氧时的峰值22.1+/-2.3(P<0.01)，而毛细血管压(Pc)无明显变化。与未处理的常氧对照组相比，低氧组的Pa值和Pc值均无明显变化(Normox，n=6，P>0.05)。正常氧组(0.070+/-0.014)、低氧组(0.082+/-0.024)和低氧组(0.057+/-0.017)的KF(平均+/-SE单位：mL.min-1.Torr-0.014 g-1)无显著差异(P>0.05)。尽管COI显著增强对急性肺泡低氧的升压反应，但无论COI如何，低氧既不增加Pc，也不增加血管通透性。
Hemodynamics and vascular permeability were studied during acute alveolar hypoxia in isolated canine lung lobes perfused at constant flow with autogenous blood. Hypoxia was induced in the presence (COI + Hypox, n = 6) or absence (Hypox, n = 6) of cyclooxygenase inhibition (COI) with indomethacin or meclofenamate. Hypoxic ventilation reduced blood PO2 from 143 to 25-29 Torr without a change in PCO2. During hypoxia a capillary filtration coefficient (Kf) was obtained gravimetrically as an index of vascular permeability to water. In COI + Hypox, pulmonary arterial pressure (Pa) increased from 11.5 +/- 0.7, post-COI normoxia, to a peak of 22.1 +/- 2.3 during hypoxia (P less than 0.01) without a change in capillary pressure (Pc). In contrast, hypoxia changed neither Pa nor Pc in Hypox relative to an untreated normoxic control group (Normox, n = 6, P greater than 0.05). Kfs (means +/- SE in ml.min-1.Torr-1.100 g-1) for Normox (0.070 +/- 0.014), Hypox (0.082 +/- 0.024), and COI + Hypox (0.057 +/- 0.017) did not differ from one another (P greater than 0.05). Although COI markedly enhanced the pressor response to acute alveolar hypoxia, hypoxia increased neither Pc nor vascular permeability regardless of COI.